Modeling Recovery of Rhythmic Activity: Hypothesis for the role of a calcium pump.
Modeling Recovery of Rhythmic Activity: Hypothesis for the role of a calcium pump.
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节律活动恢复建模：钙泵作用的假设。
DOI：
10.1016/j.neucom.2006.10.051
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发表时间：
2007
期刊：
影响因子：
6
通讯作者：
Golowasch,Jorge
中科院分区：
文献类型：
--
作者：
Zhang,Yili;Golowasch,Jorge
甲壳类动物的幽门网络是研究中枢模式生成网络扰动/损伤后功能恢复的模型系统。该网络在解剖学和功能上都有很好的特征，但其活性稳定或恢复的细胞机制尚不清楚。在先前的理论研究中，离子电导的长期活动依赖性调节被证明足以解释节律性活动在由于去除中枢输入而丢失后的恢复。然而，这个模型并没有捕捉到权力下放之后和最终稳定复苏之前的复杂的时间活动动态（bouting）。在这里，我们建立了一个有条件的起搏神经元的离子电导水平取决于活动，如前所述，但也包括一个缓慢的活动依赖性调节钙的摄取（和释放）的模型。细胞内Ca 2+传感器代表酶途径，调节Ca 2+泵活性以及Ca 2+和K+电导。我们的模型表明，活动依赖性调节钙的摄取以及离子电流相互作用，产生复杂的变化，幽门活动，以下权力下放。由NIMH 64711和NSF IBN-0090250支持。
The pyloric network of crustaceans is a model system for the study of the recovery of function after perturbation/injury of a central pattern-generating network. The network is well characterized anatomically and functionally, yet the cellular mechanism underlying the stabilization or recovery of its activity is not known. In a previous theoretical study long-term activity-dependent regulation of ionic conductances was shown to be sufficient to explain the recovery of rhythmic activity after it is lost due to removal of central input. This model, however, did not capture the complex temporal activity dynamics (bouting) that follows decentralization and that precedes the final stable recovery. Here we build a model of a conditional pacemaker neuron whose ionic conductance levels depend on activity as before, but also includes a slow activity-dependent regulation of Ca2+uptake (and release). Intracellular Ca2+sensors, representing enzymatic pathways, regulate the Ca2+pump activity as well as Ca2+and K+conductances. Our model suggests that the activity-dependent regulation of Ca2+uptake as well as ionic currents interact to generate the complex changes in pyloric activity that follows decentralization. Supported by NIMH 64711 and NSF IBN-0090250.