Genetic linkage of mild malaria to the major histocompatibility complex in Gambian children: Study of affected sibling pairs
Genetic linkage of mild malaria to the major histocompatibility complex in Gambian children: Study of affected sibling pairs
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DOI：
10.1136/bmj.315.7100.96
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发表时间：
1997-07-12
影响因子：
--
通讯作者：
Whittle, H
中科院分区：
文献类型：
--
作者：
Jepson, A;SisayJoof, F;Whittle, H
病例对照研究表明，主要组织相容性复合体基因影响严重恶性疟原虫病（脑型疟疾或严重贫血）的表现和结果。为了评估这些基因在轻度疾病中的作用，我们对这种表型一致的同胞对进行了遗传分析。受影响的同胞对方法比较了在由血统遗传的相同（ibd）的标记基因座上亲本等位基因的观察和预期分布。在任何一个基因座上，一对兄弟姐妹可能以25%：50%：25%的比例通过随机分离共享0、1或2个等位基因。如果一个基因座与疾病有遗传联系，受影响的兄弟姐妹在该基因座上共享的相同等位基因数量将高于预期。
Case-control studies have shown that genes for the major histocompatibility complex influence the presentation and outcome of severe Plasmodium falciparum disease (cerebral malaria or severe anaemia). 1 2 To assess the role of these genes in mild disease, we conducted a genetic analysis of sibling pairs concordant for this phenotype. The affected sib-pair method compares the observed and expected distribution of parental alleles at marker loci inherited identical by descent (ibd). At any locus, a pair of siblings may share 0, 1, or 2 alleles in the ratio 25%: 50%: 25%, by random segregation. If a locus is genetically linked to disease, affected siblings will share a higher number of alleles identical by descent at that locus than expected.