Adipokines, metabolic dysfunction and illness course in bipolar disorder
Adipokines, metabolic dysfunction and illness course in bipolar disorder
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DOI：
10.1016/j.jpsychires.2015.12.003
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发表时间：
2016-03-01
影响因子：
4.8
通讯作者：
Brietzke, Elisa
中科院分区：
文献类型：
--
作者：
Mansur, Rodrigo B.;Rizzo, Lucas B.;Brietzke, Elisa
重复证据表明，双相情感障碍患者受到代谢合并症的影响不同，并且其发生是双相情感障碍结果的关键中介和/或调节因素。本研究旨在探讨脂肪因子对双相情感障碍 (BD) 病程的作用及其与代谢合并症（即 2 型糖尿病、肥胖）的关系。我们测量了 59 名 BD 患者和 28 名健康志愿者的血浆脂联素和瘦素水平，以及人体测量和代谢参数。我们的结果表明，在女性参与者中，BD 患者的脂联素水平低于健康对照者 (p = 0.017)。在BD人群中，脂联素水平与空腹血糖（r = -0.291，p = 0.047）、空腹胰岛素（r = -0.332，p = 0.023）、C肽（r = 0.040，p = 0.040）、稳态模型评估胰岛素抵抗（r = -0.411，p = 0.004）、HDL相关（r = 0.508，p < 0.001）、VLDL（r = -0395，p = 0.005）和甘油三酯（r = -0.310，p = 0.030）。调整年龄、性别和体重指数后，双相情感障碍和脂联素水平较低（即 < 7.5 μg/ml）的个体的情绪发作次数较多（p < 0.001），精神科住院次数较少（p = 0.007），抑郁症状较高（p < 0.001），功能水平较低（p = 0.020）。总之，脂联素水平，无论是直接的还是作为代谢功能障碍的指标，都与 BD 的不良病程独立相关。 (C) 2015 Elsevier Ltd. 保留所有权利。
Replicated evidence indicates that individuals with BD are differentially affected by metabolic comorbidities and that its occurrence is a critical mediator and/or moderator of BD outcomes. This study aimed to explore the role of adipokines on bipolar disorder (BD) course and its relationship with metabolic comorbidities (i.e. type 2 diabetes mellitus, obesity). We measured plasma levels of adiponectin and leptin, as well as anthropometric and metabolic parameters of 59 patients with BD and 28 healthy volunteers. Our results showed that, in female participants, adiponectin was lower in individuals with BD, relative to healthy controls (p = 0.017). In the BD population, adiponectin levels were correlated with fasting glucose (r = -0.291, p = 0.047), fasting insulin (r = -0.332, p = 0.023), C-peptide (r = 0.040, p = 0.040), homeostatic model assessment-insulin resistance (r = -0.411, p = 0.004), HDL (r = 0.508, p < 0.001), VLDL (r = -0395, p = 0.005) and triglycerides (r = -0.310, p = 0.030). After adjustment for age, gender and BMI, individuals with BD and low adiponectin levels (i.e. < 7.5 mu g/ml), had a higher number of mood episodes (p < 0.001), lower number of psychiatric hospitalizations (p = 0.007), higher depressive symptoms (p < 0.001) and lower levels of functioning (p = 0.020). In conclusion, adiponectin levels, either directly or as a proxy of metabolic dysfunction, is independently associated with an un-favorable course of illness in BD. (C) 2015 Elsevier Ltd. All rights reserved.