Dysregulation of peripheral endocannabinoid levels in hyperglycernia and obesity: Effect of high fat diets
Dysregulation of peripheral endocannabinoid levels in hyperglycernia and obesity: Effect of high fat diets
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DOI：
10.1016/j.mce.2008.01.026
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发表时间：
2008-04-16
影响因子：
4.1
通讯作者：
Di Marzo, Vincenzo
中科院分区：
文献类型：
--
作者：
Matias, Isabel;Petrosino, Stefania;Di Marzo, Vincenzo
越来越多的证据表明，内源性大麻素（EC）信号传导在高血糖症和肥胖症期间失调，特别是在参与控制能量摄入和加工的组织（例如肝脏、白色脂肪组织和胰腺）中花生四烯酸（AEA）和/或2-花生四烯酸甘油（2-AG）浓度的水平下。在这里，我们回顾了以前的证据，并提供了新的数据，可能失调的EC水平的器官内分泌功能（肾上腺和甲状腺），参与能量消耗（棕色脂肪组织和骨骼肌），或受代谢紊乱后果的影响（心脏和肾脏），从用两种不同的高脂肪饮食（HFD）喂养3、8和14周的小鼠获得，具有不同的脂肪酸组成和对空腹葡萄糖水平的影响。AEA或2-AG或两者的水平在统计学上显著升高（在骨骼肌、心脏和肾脏）或降低（在甲状腺），这些变化先于或伴随明显肥胖和/或高血糖症的发展。在肾上腺中，首先观察到EC水平降低，然后升高。在棕色脂肪，一个非常早期的海拔AEA和2-AG的标准化水平，观察到的饮食之一，而延迟下降的解释由HFDs诱导的脂肪组织重量的量的增加。这些和以前的研究结果的潜在影响，在一般框架内的EC系统的控制代谢，内分泌和心血管和肾脏功能的建议的作用进行了讨论。(C)2008爱思唯尔爱尔兰有限公司保留所有权利。
Increasing evidence indicates that endocannabinoid (EC) signalling is dysregulated during hyperglycemia and obesity, particularly at the level of anandamide (AEA) and/or 2-arachidonoylglycerol (2-AG) concentrations in tissues involved in the control of energy intake and processing, such as the liver, white adipose tissue and pancreas. Here we review this previous evidence and provide new data on the possible dysregulation of EC levels in organs with endocrine function (adrenal glands and thyroid), involved in energy expenditure (brown adipose tissue and skeletal muscle), or affected by the consequences of metabolic disorders (heart and kidney), obtained from mice fed for 3, 8 and 14 weeks with two different high fat diets (HFDs), with different fatty acid compositions and impact on fasting glucose levels. Statistically significant elevations (in the skeletal muscle, heart and kidney) or reductions (in the thyroid) of the levels of either AEA or 2-AG, or both, were found. Depending on the diet, these changes preceded or accompanied the development of overt obesity and/or hyperglycemia. In the adrenal gland, first a reduction and then an elevation of EC levels were observed. In the brown fat, a very early elevation of both AEA and 2-AG normalized levels was observed with one of the diets, whereas delayed decreases were explained by an increase of the amount of fat tissue weight induced by the HFDs. The potential implications of these and previous findings in the general framework of the proposed roles of the EC system in the control of metabolic, endocrine and cardiovascular and renal functions are discussed. (C) 2008 Elsevier Ireland Ltd. All rights reserved.