Potential Role of Coregistered Photoacoustic and Ultrasound Imaging in Ovarian Cancer Detection and Characterization
Potential Role of Coregistered Photoacoustic and Ultrasound Imaging in Ovarian Cancer Detection and Characterization
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DOI：
10.1593/tlo.10187
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发表时间：
2011-02-01
影响因子：
5
通讯作者：
Zhu, Quing
中科院分区：
文献类型：
--
作者：
Aguirre, Andres;Ardeshirpour, Yasaman;Zhu, Quing
目前，还没有足够的技术来检测早期卵巢癌。大多数卵巢癌是在癌症已经转移到身体其他部位时被发现的。因此，卵巢癌是所有妇科癌症中死亡率最高的，5年生存率不超过30%。因此，迫切需要改进目前的诊断技术。光声成像(PAI)是一种新兴的检查手段，在辅助超声无创检测卵巢癌方面具有很大的潜力。在这篇文章中，我们报告了33个体外人卵巢的超声和PAI联合成像的首次研究。对光声图像的评估揭示了卵巢中的光吸收分布，这与血管的分布和数量直接相关。对卵巢光吸收水平的量化表明，在绝经后组中，恶性卵巢的光吸收明显高于正常卵巢(P=0.0237)。对于这两组，我们获得了83%的敏感性和83%的特异性。这一结果表明，PAI是提高卵巢癌超声诊断的一种有前途的方法。
Currently, there is no adequate technology to detect early stage ovarian cancers. Most of the cancers in the ovary are detected when the cancer has already metastasized to other parts of the body. As a result, ovarian cancer has the highest mortality of all gynecologic cancers with a 5-year survival rate of 30% or less. Thus, there is an urgent need to improve the current diagnostic techniques. Photoacoustic imaging (PAI) is an emerging modality with a great potential to assist ultrasound for detecting ovarian cancer noninvasively. In this article, we report the first study of coregistered ultrasound and PAI of 33 ex vivo human ovaries. An assessment of the photoacoustic images has revealed light absorption distribution in the ovary, which is directly related to the vasculature distribution and amount. Quantification of the light absorption levels in the ovary has indicated that, in the postmenopausal group, malignant ovaries showed significantly higher light absorption than normal ones (P = .0237). For these two groups, we have obtained a sensitivity of 83% and a specificity of 83%. This result suggests that PAI is a promising modality for improving ultrasound diagnosis of ovarian cancer.