New wrinkles in lipoprotein lipase biology.
New wrinkles in lipoprotein lipase biology.
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DOI：
10.1097/mol.0b013e32834d0b33
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发表时间：
2012-02
影响因子：
4.4
通讯作者：
Young SG
中科院分区：
文献类型：
--
作者：
Davies BS;Beigneux AP;Fong LG;Young SG
我们总结了GPIHBP1的最新进展，GPIHBP1是一种将脂蛋白脂酶（LPL）转运到毛细血管腔的分子，并讨论了几个新研究的分子，这些分子对LPL活性的调节很重要。LPL是负责富含磷脂酰肌醇的脂蛋白的脂解加工的酶，与多种蛋白质相互作用，并在多个水平上受到调节。LPL活性的几种调节剂已被发现多年，并已被彻底研究，但最近才发现几种，包括将LPL转运到毛细血管腔的内皮细胞蛋白，降低LPL转录水平的microRNA，靶向LPL摄取和降解的分选蛋白，以及增加调节LPL活性的载脂蛋白表达的转录因子。LPL的适当调节对于控制脂质营养物质向组织的递送是重要的。最近的研究已经确定GPIHBP1是将LPL转运到毛细血管腔的分子，并且还确定了对调节LPL活性潜在重要的其他分子。这些新发现为理解脂解和高脂血症的基本机制打开了新的大门。
We summarize recent progress on GPIHBP1, a molecule that transports lipoprotein lipase (LPL) to the capillary lumen, and discuss several newly studied molecules that appear important for the regulation of LPL activity. LPL, the enzyme responsible for the lipolytic processing of triglyceride-rich lipoproteins, interacts with multiple proteins and is regulated at multiple levels. Several regulators of LPL activity have been known for years and have been investigated thoroughly, but several have been identified only recently, including an endothelial cell protein that transports LPL to the capillary lumen, a microRNA that reduces LPL transcript levels, a sorting protein that targets LPL for uptake and degradation, and a transcription factor that increases the expression of apolipoproteins that regulate LPL activity. Proper regulation of LPL is important for controlling the delivery of lipid nutrients to tissues. Recent studies have identified GPIHBP1 as the molecule that transports LPL to the capillary lumen, and have also identified other molecules that are potentially important for regulating LPL activity. These new discoveries open new doors for understanding basic mechanisms of lipolysis and hyperlipidemia.