Alteration of Spontaneous Brain Activity After Hypoxia-Reoxygenation: A Resting-State fMRI Study
Alteration of Spontaneous Brain Activity After Hypoxia-Reoxygenation: A Resting-State fMRI Study
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缺氧-复氧后自发脑活动的改变：静息态功能磁共振成像研究
DOI：
10.1089/ham.2016.0083
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发表时间：
2017
影响因子：
2.1
通讯作者：
Fan Ming
中科院分区：
文献类型：
--
作者：
Zhang Jiaxing;Chen Ji;Fan Cunxiu;Li Jinqiang;Lin Jianzhong;Yang Tianhe;Fan Ming
张嘉兴、季晨、范存秀、李金强、林建中、杨天河、范明。缺氧-复氧后自发脑活动的改变：一项静息状态的fMRI研究.High Alt Med Biol.18：20-26,2017.-本研究旨在探讨缺氧-复氧对脑内自发神经元活动的影响.招募了16名海平面(SL)士兵(20.5年 ± 0.7年)，他们在高海拔(2300-4400 m)的边境驻扎了两年，然后下降到海平面1至7天。对照组由16名匹配的SL原住民组成。分析静息状态下局部脑功能磁共振成像信号的低频波动幅度(ALF)和脑区之间的功能连通性(FC)。HA受试者双侧枕叶皮质内多个部位的ALF值显著增加，右侧前岛叶及延伸至尾状核、壳核、额下眶皮质、颞极和颞上回的ALF值显著降低；右侧岛叶的ALF值降低与低呼吸测量值呈正相关。HA患者右侧脑岛Fc增加，右侧颞叶上回、中央后回、枕盖、缘上回、额下三角区Fc增加。说明缺氧-复氧对大鼠脑内自发神经元活动有影响。岛叶神经元活性降低可能与呼吸驱动减弱有关，而岛叶FC的增加可能与中枢代偿有关。
Zhang, Jiaxing, Ji Chen, Cunxiu Fan, Jinqiang Li, Jianzhong Lin, Tianhe Yang, and Ming Fan. Alteration of spontaneous brain activity after hypoxia-reoxygenation: A resting-state fMRI study.High Alt Med Biol.18:20–26, 2017.—The present study was designed to investigate the effect of hypoxia–reoxygenation on the spontaneous neuronal activity in brain. Sixteen sea-level (SL) soldiers (20.5 ± 0.7 years), who garrisoned the frontiers in high altitude (HA) (2300–4400 m) for two years and subsequently descended to sea level for one to seven days, were recruited. Control group consisted of 16 matched SL natives. The amplitude of low-frequency fluctuations (ALFF) of regional brain functional magnetic resonance imaging signal in resting state and functional connectivity (FC) between brain regions was analyzed. HA subjects showed significant increases of ALFF at several sites within the bilateral occipital cortices and significant decreases of ALFF in the right anterior insula and extending to the caudate, putamen, inferior frontal orbital cortex, temporal pole, and superior temporal gyrus; lower ALFF values in the right insula were positively correlated with low respiratory measurements. The right insula in HA subjects had increases of FC with the right superior temporal gyrus, postcentral gyrus, rolandic operculum, supramarginal gyrus, and inferior frontal triangular area. We thus demonstrated that hypoxia–reoxygenation had influence on the spontaneous neuronal activity in brain. The decrease of insular neuronal activity may be related to the reduction of ventilatory drive, while the increase of FC with insula may indicate a central compensation.