Theoretical advantages of a triaxial optically pumped magnetometer magnetoencephalography system.
Theoretical advantages of a triaxial optically pumped magnetometer magnetoencephalography system.
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DOI：
10.1016/j.neuroimage.2021.118025
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发表时间：
2021-08-01
期刊：
影响因子：
5.7
通讯作者：
Bowtell R
中科院分区：
文献类型：
--
作者：
Brookes MJ;Boto E;Rea M;Shah V;Osborne J;Holmes N;Hill RM;Leggett J;Rhodes N;Bowtell R
光泵磁力计（OPM）是一种可行的手段来检测由人脑活动产生的磁场。与传统的探测器（超导量子干涉装置）相比，OPM体积小，重量轻，灵活，无需低温。这导致了脑磁图（MEG）仪器的一步变化，使“可穿戴”扫描仪平台能够适应任何头部尺寸，能够在受试者移动时获取数据，并提供更高的数据质量。尽管许多研究已经显示了“OPM-MEG”的功效，但一个相对未开发的优点涉及改进的阵列设计。具体地，OPM使得能够同时测量沿着多个轴（不同于如在大多数常规MEG系统中使用的单个径向取向）的磁场分量沿着。这使得在所有传感器的磁场矢量的特性，提供额外的信息，有可能改善源重建。在这里，我们进行了理论分析的关键参数，应优化有效的源重建。我们表明，这些参数可以通过明智的阵列设计，结合三轴脑磁图测量进行优化。使用模拟，我们演示了如何三轴阵列提供了一个显着的改善我们的能力，区分真实的大脑活动的磁干扰源（外部的大脑）。此外，一个三轴系统示出，以提供一个显着的改善，在消除由头部运动引起的伪影。理论结果的补充实验记录表明，改善干扰减少。这些发现为未来如何设计具有更高性能的OPM-MEG阵列提供了新的见解。
The optically pumped magnetometer (OPM) is a viable means to detect magnetic fields generated by human brain activity. Compared to conventional detectors (superconducting quantum interference devices) OPMs are small, lightweight, flexible, and operate without cryogenics. This has led to a step change in instrumentation for magnetoencephalography (MEG), enabling a “wearable” scanner platform, adaptable to fit any head size, able to acquire data whilst subjects move, and offering improved data quality. Although many studies have shown the efficacy of ‘OPM-MEG’, one relatively untapped advantage relates to improved array design. Specifically, OPMs enable the simultaneous measurement of magnetic field components along multiple axes (distinct from a single radial orientation, as used in most conventional MEG systems). This enables characterisation of the magnetic field vector at all sensors, affording extra information which has the potential to improve source reconstruction. Here, we conduct a theoretical analysis of the critical parameters that should be optimised for effective source reconstruction. We show that these parameters can be optimised by judicious array design incorporating triaxial MEG measurements. Using simulations, we demonstrate how a triaxial array offers a dramatic improvement on our ability to differentiate real brain activity from sources of magnetic interference (external to the brain). Further, a triaxial system is shown to offer a marked improvement in the elimination of artefact caused by head movement. Theoretical results are supplemented by an experimental recording demonstrating improved interference reduction. These findings offer new insights into how future OPM-MEG arrays can be designed with improved performance.
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影响因子：
3.7
作者：
Boto E;Bowtell R;Krüger P;Fromhold TM;Morris PG;Meyer SS;Barnes GR;Brookes MJ
通讯作者：
Brookes MJ
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影响因子：
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