Sex differences in the cerebral function associated with processing of aversive stimuli by schizophrenia patients
Sex differences in the cerebral function associated with processing of aversive stimuli by schizophrenia patients
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DOI：
10.1080/00048670601109907
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发表时间：
2007-02-01
影响因子：
4.6
通讯作者：
Stip, Emmanuel
中科院分区：
文献类型：
--
作者：
Mendrek, Adrianna;Mancini-Marie, Adham;Stip, Emmanuel
目的：各种情绪处理受损被认为是精神分裂症的基本特征之一。在最近的研究中，观察到精神分裂症患者与悲伤经历相关的大脑功能存在有趣的性别差异。本研究的目的是探讨暴露于厌恶刺激时的这种现象。方法：15 名男性和 10 名女性，经 DSM-IV 诊断为精神分裂症，在观看交替的负面和中性图片块时接受功能性磁共振成像 (WRI)。使用统计参数映射（SPM99）软件中的随机效应模型对数据进行分析。结果：负面刺激的处理在男性的丘脑、小脑、颞叶、枕叶和后扣带皮层中引起显着更大的激活，而女性在左额中回表现出更大的激活。结论：精神分裂症患者大脑激活的性别差异与在一般人群中观察到的情况不同。在暴露和经历负面影响期间。因此，本研究支持并扩展了作者在功能神经解剖学水平上对精神分裂症异常性别二态性的初步观察，表明女性受试者潜在的男性化和男性精神分裂症受试者的女性化。
Objective: Impaired processing of various emotions is considered one of the fundamental features of schizophrenia. In the recent study intriguing sex differences were observed in the cerebral function associated with the experience of sadness in schizophrenia patients. The aim of the present study was to explore this phenomenon during exposure to aversive stimuli.Method: Fifteen men and 10 women with the DSM-IV diagnosis of schizophrenia underwent functional magnetic resonance imaging (WRI) while viewing alternating blocks of negative and neutral pictures. Data were analysed using random-effects model within statistical parametric mapping (SPM99) software.Results: Processing of negative stimuli evoked significantly greater activations in men in the thalamus, cerebellum, temporal, occipital and posterior cingulate cortex, while women exhibited greater activations in the left middle frontal gyrus.Conclusions: The sex differences in the cerebral activations in schizophrenia patients deviate from what has been observed in the general population during exposure and experience of negative affect. As such the present study supports and extends the authors' preliminary observation of the anomalous sexual dimorphism in schizophrenia at the functional neuroanatomical level, suggesting potential masculinization of female subjects and feminization of male subjects with schizophrenia.