Adherence to Pre-exposure Prophylaxis in Black Men Who Have Sex with Men and Transgender Women in a Community Setting in Harlem, NY
Adherence to Pre-exposure Prophylaxis in Black Men Who Have Sex with Men and Transgender Women in a Community Setting in Harlem, NY
复制标题
DOI：
10.1007/s10461-020-02901-6
复制
发表时间：
2020-05-08
影响因子：
4.4
通讯作者：
Hirsch-Moverman, Y.
中科院分区：
文献类型：
--
作者：
Colson, P. W.;Franks, J.;Hirsch-Moverman, Y.
虽然口服暴露前预防（PrEP）已被证明对艾滋病毒预防有效，但必须持续使用才能实现其预期效果。我们比较了在纽约哈莱姆社区诊所就诊的黑人MSM和TGW中增强的PrEP（enPrEP）依从性支持与标准护理（sPrEP）的有效性。EnPrEP包括同行导航、面对面/在线支持小组和短信。在季度访谈中收集的过去30天的自我报告依从性定义为>= 57%。粗分析和调整后的分析检查了与依从性相关的因素。共有204名受试者入组并随机分组; 35%失访。12个月时PrEP依从性为30%;未观察到干预效应（p = 0.69）。多变量回归分析发现，低依从性与低教育和抑郁症状相关。我们发现，加强依从性干预并没有改善PrEP依从性。调查结果指出，需要创新的方法来提高黑人男同性恋者和TGW之间的PrEP依从性。临床试验注册NCT 02167386，2014年6月19日
While oral pre-exposure prophylaxis (PrEP) has proven efficacious for HIV prevention, consistent use is necessary to achieve its intended impact. We compared effectiveness of enhanced PrEP (enPrEP) adherence support to standard of care (sPrEP) among Black MSM and TGW attending a community clinic in Harlem, NY. EnPrEP included peer navigation, in-person/online support groups, and SMS messages. Self-reported adherence over previous 30 days, collected in quarterly interviews, was defined as >= 57%. Crude and adjusted analyses examined factors associated with adherence. A total of 204 participants were enrolled and randomized; 35% were lost to follow-up. PrEP adherence was 30% at 12-months; no intervention effect was observed (p = 0.69). Multivariable regression analysis found that lower adherence was associated with low education and depressive symptoms. We found that an enhanced adherence intervention did not improve PrEP adherence. Findings point to the need for innovative methods to improve PrEP adherence among Black MSM and TGW. Clinical Trial Registration NCT02167386, June 19, 2014