The methodology of the GUSTO cohort study: a novel approach in studying pediatric allergy.
The methodology of the GUSTO cohort study: a novel approach in studying pediatric allergy.
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DOI：
10.5415/apallergy.2012.2.2.144
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发表时间：
2012-04
影响因子：
1.7
通讯作者：
van Bever HP
中科院分区：
文献类型：
--
作者：
Soh SE;Lee SS;Hoon SW;Tan MY;Goh A;Lee BW;Shek LP;Teoh OH;Kwek K;Saw SM;Godfrey K;Chong YS;Gluckman P;van Bever HP
在新加坡成长迈向健康结果（GUSTO）是新加坡迄今为止最大的出生队列研究。GUSTO的主要目的是评估发育因素在代谢妥协的早期途径中的作用。收集了父母和后代的一系列环境暴露的详细数据，过敏性疾病是婴儿和儿童时期评估的一些结果之一。在GUSTO的过敏领域，这项综合研究将描述亚洲背景下过敏表现和不同表型的流行病学，并有助于阐明代谢疾病与过敏的关联。还将探讨表观遗传机制和与其他儿童疾病的关联。本报告的目的是重点介绍GUSTO的方法，并提出类似的方法（即，儿童过敏综合队列研究）。2009年开始招募1 163名头三个月的孕妇。母亲和孩子在整个怀孕期间接受随访，随访将持续到孩子满3岁。初步结果显示，39.8%的母亲有至少一种过敏性疾病的个人病史，包括哮喘，湿疹和过敏性鼻炎。进一步的数据收集和分析仍在进行中。过敏症是一种复杂的疾病谱，具有许多不太了解的方面。正在进行的GUSTO队列研究，其纵向设计和多学科的性质，可能会提供新的见解发展对过敏的影响。作为一项基于新加坡的研究，它将是东南亚第一个综合过敏队列，其中招募开始于怀孕期间。
Growing Up in Singapore Towards healthy Outcomes (GUSTO) is Singapore's largest birth cohort study to date. The main aim of GUSTO is to evaluate the role of developmental factors in the early pathways to metabolic compromise. Detailed data is collected for a range of environmental exposures in the parents and offspring, and allergic disorders are among a number of outcomes assessed in infancy and childhood. Under the Allergy domain of GUSTO, this integrated study will describe the epidemiology of allergic manifestations and different phenotypes in the Asian context and help shed light on the association of metabolic disease to allergy. Epigenetic mechanisms and associations with other childhood disorders will also be explored. The aim of this report is to focus on methodology of GUSTO, and to suggest similar approaches (i.e., integrated cohort studies on pediatric allergy) worldwide. Recruitment commenced in 2009 with a cohort of 1,163 pregnant mothers in their first trimester. The mothers and children were followed throughout pregnancy and follow-up will continue until the child reaches 3 years of age. Preliminary results showed that 39.8% of the mothers had a personal history of having at least one allergic disease, which included asthma, eczema and allergic rhinitis. Further data collection and analyses are still ongoing. Allergy is a complex spectrum of disorders with numerous poorly-understood aspects. The ongoing GUSTO cohort study, with its longitudinal design and multi-disciplinary nature, may provide new insights into developmental influences on allergy. As a Singapore-based study, it will be the first integrated allergy cohort in Southeast Asia, of which recruitment started during pregnancy.