Yoga lifestyle intervention reduces blood pressure in HIV-infected adults with cardiovascular disease risk factors.
Yoga lifestyle intervention reduces blood pressure in HIV-infected adults with cardiovascular disease risk factors.
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DOI：
10.1111/j.1468-1293.2009.00801.x
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发表时间：
2010-07-01
期刊：
影响因子：
3
通讯作者：
Yarasheski KE
中科院分区：
文献类型：
--
作者：
Cade WT;Reeds DN;Mondy KE;Overton ET;Grassino J;Tucker S;Bopp C;Laciny E;Hubert S;Lassa-Claxton S;Yarasheski KE
感染人类免疫缺陷病毒（HIV）的人患心血管疾病（CVD）的风险增加。降低艾滋病毒CVD风险的安全有效干预措施是高度优先事项。我们进行了一项前瞻性、随机、对照研究，以评估瑜伽生活方式干预是否比匹配的对照组更能改善HIV感染成年人的CVD危险因素、病毒学或免疫学状态或生活质量。60名有轻度至中度心血管疾病风险的HIV感染成年人被分配到20周的监督瑜伽练习或标准护理治疗。基线和第20周的指标为：2小时口服葡萄糖耐量试验和胰岛素监测、身体组成、空腹血脂/脂蛋白谱、静息血压、CD 4 + T细胞数量和血浆HIV RNA，以及医学结局研究SF-36健康相关生活质量量表。瑜伽组的静息收缩压和舒张压（−5±2和−3±1 mmHg）比标准护理组（+1 2和+2 2 mmHg）降低更多（p=0.04），尽管瑜伽后体重、脂肪量、促动脉粥样硬化脂质或葡萄糖耐量或整体生活质量没有更大的降低。免疫和病毒学状态未受到不良影响。在传统的生活方式改变中，瑜伽是一种低成本，易于管理，非药物，流行的行为干预措施，可以降低具有轻度至中度CVD风险因素的高血压前期HIV感染成年人的血压。
People living with human immunodeficiency virus infection (HIV) are at increased risk for developing cardiovascular disease (CVD). Safe and effective interventions for lowering CVD risk in HIV are high priorities. We conducted a prospective, randomized, controlled study to evaluate whether a yoga lifestyle intervention improves CVD risk factors, virologic or immunologic status, or quality of life in HIV-infected adults more than in a matched control group. Sixty HIV-infected adults with mild-moderate CVD risk were assigned to 20 wks of supervised yoga practice or standard of care treatment. Baseline and week 20 measures were; 2hr-oral glucose tolerance test with insulin monitoring, body composition, fasting serum lipid/lipoprotein profile, resting blood pressures, CD4+ T-cell number and plasma HIV RNA, and the Medical Outcomes Study SF-36 health-related quality of life inventory. Resting systolic and diastolic blood pressures were reduced more (p=0.04) in the yoga group (−5±2 and −3±1 mmHg) than in the standard of care group (+1±2 and +2±2 mmHg), despite no greater reduction in body weight, fat mass, proatherogenic lipids, or improvements in glucose tolerance or overall quality of life after yoga. Immune and virologic status was not adversely affected. Among traditional lifestyle modifications, yoga is a low cost, simple to administer, non-pharmacological, popular behavioral intervention that can lower blood pressure in pre-hypertensive HIV-infected adults with mild-moderate CVD risk factors.
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DOI：
10.1089/107555304323062257
发表时间：
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