Reaction of Hydrogen Sulfide with Disulfide and Sulfenic Acid to Form the Strongly Nucleophilic Persulfide
Reaction of Hydrogen Sulfide with Disulfide and Sulfenic Acid to Form the Strongly Nucleophilic Persulfide
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DOI：
10.1074/jbc.m115.672816
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发表时间：
2015-11-06
影响因子：
4.8
通讯作者：
Alvarez, Beatriz
中科院分区：
文献类型：
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作者：
Cuevasanta, Ernesto;Lange, Mike;Alvarez, Beatriz
背景：硫化氢 (H2S) 调节哺乳动物的生理过程。结果：评估了 H2S 与二硫化物 (RSSR) 和白蛋白亚磺酸 (RSOH) 形成过硫化物 (RSSH) 的反应性。结论：H2S 的反应性低于硫醇。过硫化物具有增强的亲核性。意义：这项动力学研究有助于合理化与氧化硫醇衍生物的反应对 H2S 生物学的贡献。
Background: Hydrogen sulfide (H2S) modulates physiological processes in mammals.Results: The reactivity of H2S toward disulfides (RSSR) and albumin sulfenic acid (RSOH) to form persulfides (RSSH) was assessed.Conclusion: H2S is less reactive than thiols. Persulfides have enhanced nucleophilicity.Significance: This kinetic study helps rationalize the contribution of the reactions with oxidized thiol derivatives to H2S biology.