Trimethylamine N-oxide (TMAO) Is not Associated with Cardiometabolic Phenotypes and Inflammatory Markers in Children and Adults.
Trimethylamine N-oxide (TMAO) Is not Associated with Cardiometabolic Phenotypes and Inflammatory Markers in Children and Adults.
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DOI：
10.1093/cdn/nzaa179
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发表时间：
2021-01
影响因子：
4.8
通讯作者：
O'Sullivan JM
中科院分区：
文献类型：
--
作者：
Andraos S;Jones B;Lange K;Clifford SA;Thorstensen EB;Kerr JA;Wake M;Saffery R;Burgner DP;O'Sullivan JM
三甲胺N氧化物（TMAO）是饮食和微生物组衍生的代谢产物，并且在患有心脏代谢性疾病的个体中进行了不良心脏代谢结果研究的拟议生物标志物。
我们的目的是研究血浆TMAO浓度及其前体[肉碱，胆碱，甜菜碱和二甲基甘氨酸（DMG）]与代谢综合征（METS）得分，临床前心血管表型和炎症生物标志物（即高稳定蛋白质蛋白质蛋白质蛋白质蛋白质）的关联在人群衍生的儿童及其父母的队列中，血清糖蛋白乙酰基）。
使用UHPLC与1166名儿童（平均年龄11 y±0.5 y，51％女性）和1324名成年人（44 y±5.1 y，87％，87％，平均年龄11 y±0.5 y，51％，平均年龄11 y±0.5 y，51％，平均年龄11 y±0.5 y，51％，平均年龄11 y±0.5 y，51％，平均年龄11 y±0.5 y，51％，平均年龄11 y±0.5 y，51％，平均年龄为11 y±0.5 y，51％，平均年龄为11 y±0.5 y，51％，87％女性参与澳大利亚的儿童健康检查站研究。计算家庭收入及其肌酐比率）。
TMAO前体的浓度（而不是TMAO本身）与儿童和成人的Mets，心血管表型和炎症生物标志物有关。
TMAO前体（而不是TMAO本身）与儿童和成人的炎症表型不良相关。
TMAO前体浓度可以更好地反映更广泛的人群中心脏代谢的健康和炎症状态。
Trimethylamine N-oxide (TMAO) is a diet- and microbiome-derived metabolite and a proposed biomarker of adverse cardiometabolic outcomes. TMAO studies have mainly been conducted in individuals with cardiometabolic disease, and studies in population-derived samples are limited. We aimed to investigate the associations between plasma TMAO concentrations and its precursors [carnitine, choline, betaine, and dimethylglycine (DMG)] with metabolic syndrome (MetS) scores, preclinical cardiovascular phenotypes, and inflammatory biomarkers (i.e. high-sensitivity C-reactive protein and serum glycoprotein acetyls) in a population-derived cohort of children and their parents. The concentrations of TMAO and its precursors were quantified using UHPLC coupled with tandem MS (UHPLC/MS-MS) in 1166 children (mean age 11 y ± 0.5 y, 51% female) and 1324 adults (44 y ± 5.1 y, 87% female) participating in The Growing Up in Australia's Child Health CheckPoint Study. We developed multivariable fractional polynomial models to analyze associations between TMAO, its precursors, MetS (adjusted for sex and age), and cardiovascular phenotypes (adjusted for sex, age, BMI, household income, and the urinary albumin to creatinine ratio). Pearson's correlations were computed to identify associations between TMAO, its precursors, and inflammatory biomarkers. The concentrations of TMAO precursors, but not TMAO itself, were associated with MetS, cardiovascular phenotypes, and inflammatory biomarkers in children and adults. TMAO precursors, but not TMAO itself, were associated with adverse cardiometabolic and inflammatory phenotypes in children and adults. TMAO precursor concentrations may better reflect cardiovascular health and inflammatory status within the wider population. Replication in other population settings and mechanistic studies are warranted. TMAO precursor concentrations may better reflect cardiometabolic health and inflammatory status within the wider population.