Which way was I going? Contextual retrieval supports the disambiguation of well learned overlapping navigational routes.
Which way was I going? Contextual retrieval supports the disambiguation of well learned overlapping navigational routes.
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DOI：
10.1523/jneurosci.6021-09.2010
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发表时间：
2010-05-26
期刊：
影响因子：
--
通讯作者：
Stern CE
中科院分区：
文献类型：
--
作者：
Brown TI;Ross RS;Keller JB;Hasselmo ME;Stern CE
在动物身上进行的开创性研究表明，海马体含有区分重叠导航轨迹的神经元。这些海马神经元选择性地对特定事件的背景做出反应，尽管重叠的记忆表征会干扰。本研究使用功能磁共振成像在人类中检查海马体和相关结构的作用时，参与者需要检索上下文信息，以导航良好的学习空间序列共享的共同元素。参与者在扫描仪外接受培训，从地面第一人称视角导航通过12个虚拟迷宫。十二个迷宫中有六个有重叠的部分。重叠的迷宫在不同的位置开始和结束，但在中间会聚，与另一个迷宫共享一些走廊。非重叠迷宫不与任何其他迷宫共享任何走廊。通过重叠的走廊成功导航需要检索与当前导航事件相关的上下文信息。结果显示，在重叠迷宫的成功导航过程中，与通常与空间和情景记忆相关的区域（包括海马、海马旁皮质和眶额皮质）中的非重叠迷宫相比，激活更大。当结合以前的研究，目前的研究结果表明，一个解剖学上集成的系统，包括海马，海马旁皮质，眶额皮质是至关重要的上下文相关检索的良好学习重叠的导航路线。
Groundbreaking research in animals has demonstrated that the hippocampus contains neurons which distinguish between overlapping navigational trajectories. These hippocampal neurons respond selectively to the context of specific episodes despite interference from overlapping memory representations. The present study used fMRI in humans to examine the role of the hippocampus and related structures when participants need to retrieve contextual information to navigate well-learned spatial sequences which share common elements. Participants were trained outside the scanner to navigate through twelve virtual mazes from a ground-level first-person perspective. Six of the twelve mazes shared overlapping components. Overlapping mazes began and ended at distinct locations, but converged in the middle to share some hallways with another maze. Non-overlapping mazes did not share any hallways with any other maze. Successful navigation through the overlapping hallways required the retrieval of contextual information relevant to the current navigational episode. Results revealed greater activation during the successful navigation of the overlapping mazes compared to the non-overlapping mazes in regions typically associated with spatial and episodic memory, including the hippocampus, parahippocampal cortex, and orbitofrontal cortex. When combined with previous research, the current findings suggest that an anatomically integrated system including the hippocampus, parahippocampal cortex, and orbitofrontal cortex is critical for the contextually-dependent retrieval of well-learned overlapping navigational routes.