The current understanding of the benefits, safety, and regulation of cannabidiol in consumer products.
The current understanding of the benefits, safety, and regulation of cannabidiol in consumer products.
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DOI：
10.1016/j.fct.2021.112600
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发表时间：
2021-11
影响因子：
4.3
通讯作者：
Kaminski, Norbert E.
中科院分区：
文献类型：
--
作者：
Li, Jinpeng;Carvajal, Ricardo;Bruner, Leon;Kaminski, Norbert E.
大麻二酚（CBD）在消费品中的受欢迎程度正在飙升，因为消费者正在使用CBD来促进一般健康和福祉，以及寻求缓解疾病，特别是疼痛、炎症、焦虑、抑郁和睡眠障碍。然而，目前在公共领域的数据有限，无法支持这些益处。相比之下，最近从CBD治疗Epidiolex®的临床前和临床研究中获得了大量的CBD安全性评估数据。然而，有关CBD安全使用的一些关键数据缺口仍然存在。此外，目前关于在消费品中使用CBD的规定仍然不确定，而且经常在州和联邦一级发生冲突。鉴于CBD相关产品在市场上的迅速普及，我们在这里回顾了目前对消费品中CBD的益处、安全性和法规的理解。本综述不提倡或反对在消费品中使用CBD。相反，本审查旨在评估关于CBD对健康的影响和安全性的科学现状，为未来的研究确定关键的知识空白，并提高对管理CBD在消费品中使用的现行法规的认识。
The popularity of cannabidiol (CBD) in consumer products is soaring as consumers are using CBD for general health and well-being as well as to seek relief from ailments especially pain, inflammation, anxiety, depression, and sleep disorders. However, there is limited data currently in the public domain that provide support for these benefits. By contrast, a significant amount of safety evaluation data for CBD has been obtained recently from pre-clinical and clinical studies of the CBD therapeutic Epidiolex®. Yet some key data gaps concerning the safe use of CBD still remain. Furthermore, current regulations on CBD use in consumer products remain uncertain and often conflict between the state and federal level. In light of the rapidly expanding popularity of CBD-related products in the marketplace, here we review the current understanding of the benefits, safety, and regulations surrounding CBD in consumer products. This review does not advocate for or against the use of CBD in consumer products. Rather this review seeks to assess the state-of-the-science on the health effects and safety of CBD, to identify critical knowledge gaps for future studies, and to raise the awareness of the current regulations that govern CBD use in consumer products.
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