Transforming growth factor β plays an important role in enhancing wound healing by topical application of Povidone-iodine
Transforming growth factor β plays an important role in enhancing wound healing by topical application of Povidone-iodine
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转化生长因子β在局部应用聚维酮碘促进伤口愈合方面发挥着重要作用
DOI：
10.1038/s41598-017-01116-5
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发表时间：
2017-04-20
影响因子：
4.6
通讯作者：
Ning, Jiaolin
中科院分区：
文献类型：
--
作者：
Wang, Li;Qin, Wenhan;Ning, Jiaolin
聚维酮碘（PVI）主要用作抗菌剂。已经发现0.5%PVI可以减轻由压疮引起的充血、水肿和疼痛。因此，本研究旨在评估0.5% PVI对急性皮肤伤口的影响。用10 mm无菌打孔器在雄性Sprague-Dawley大鼠的背部皮肤上产生四个全层切除伤口。两个伤口未处理，另外两个伤口在受伤后的前5天每天用含0.5%PVI的纱布包扎1小时。在用10 mg/kg SB 431542处理的大鼠背部皮肤上也产生10 mm全层切除伤口，并且所有伤口用0.5%PVI处理5天。PVI治疗通过促进α SMA和TGF β的表达、新生血管和再上皮化来促进伤口愈合。PVI治疗后白细胞介素6降低。抑制TGF β可消除PVI治疗对伤口闭合的影响。这些数据表明，即使在没有明显感染的情况下，局部应用0.5%PVI也可以通过增加TGF β的表达导致肉芽组织的形成增强来促进急性皮肤伤口愈合。
Povidone-iodine (PVI) is principally used as an antimicrobial agent. It has been found that 0.5% PVI can attenuate congestion, edema and pain induced by pressure sores. Thus this study aimed to assess the effects of 0.5% PVI on acute skin wounds. Four full-thickness excisional wounds were generated on the dorsal skin of male Sprague-Dawley rats with a 10-mm sterile punch. Two wounds were left untreated and the other two were dressed with gauze with 0.5% PVI for 1 hour per day for the first 5 days after injury. 10-mm full-thickness excisional wounds were also generated on the dorsal skin of rats treated with 10 mg/kg SB431542 and all wounds were treated with 0.5% PVI for 5 days. PVI treatment enhanced wound healing via promotion of expression of α SMA and TGF β, neovascularization and re-epithelialization. Interleukin 6 was reduced following PVI treatment. Inhibition of TGF β abolished the effect of PVI treatment on wound closure. These data show that topical application of 0.5% PVI could promote acute skin wound healing though increased expression of TGF β leading to enhanced formation of granulation tissue, even in the absence of obvious infection.