Maternal smoking during pregnancy in relation to child overweight: follow-up to age 8 years
Maternal smoking during pregnancy in relation to child overweight: follow-up to age 8 years
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DOI：
10.1093/ije/dyi218
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发表时间：
2006-02-01
影响因子：
7.7
通讯作者：
Longnecker, MP
中科院分区：
文献类型：
--
作者：
Chen, AM;Pennell, ML;Longnecker, MP
几项研究的数据表明，与不吸烟母亲的孩子相比，怀孕期间吸烟母亲的孩子可能有超重的风险。然而，这种关系的大小尚不清楚，就像它被检测到的年龄一样。方法对34866名参加美国围产期合作项目的儿童的前瞻性数据进行分析，以检查母亲怀孕吸烟与子女1、3、4、7和8岁时体重、身高和体重指数（BMI）的关系。结果：与非吸烟者的后代相比，吸烟者的后代(1)出生时体重较低，但很快就达到或超过了非吸烟者的体重；(2)身高持续下降；(3)超重的风险增加，尤其是在女孩中。例如，在7岁时，母亲在怀孕期间平均每天吸烟>= 20支的男孩的BMI指数>=第85百分位数的调整优势比为1.22(95%可信区间1.03-1.46)，女孩为1.30（1.08-1.56）。在这些数据中，母亲在怀孕期间吸烟与8岁前儿童超重风险的适度增加有关。
Background Data from several studies indicate that children of mothers who smoked during pregnancy may be at a risk of overweight compared with children of non-smoking mothers. The size of this relation, however, is unclear, as is the age at which it becomes detectable.Methods Prospective data for 34 866 children enrolled in the US Collaborative Perinatal Project were analysed to examine maternal pregnancy smoking in relation to weight, height, and body mass index (BMI) in offspring at ages 1, 3, 4, 7, and 8 years.Results Compared with offspring of non-smokers, children of smokers had (i) weight that was lower at birth but then quickly equalled or exceeded that of non-smokers, (ii) consistently decreased height, and (iii) increased risk of overweight, particularly in girls. For example, at age 7 years, the adjusted odds ratio of BMI >= 85th percentile in boys of mothers who smoked on an average >= 20 cigarettes per day while pregnant was 1.22 (95% confidence interval 1.03-1.46), and in girls it was 1.30 (1.08-1.56).Conclusions In these data, maternal smoking during pregnancy was associated with a modest increase in risk of overweight in children before the age of 8 years.