FUNCTIONAL SUBDIVISIONS OF THE RAT SOMATIC SENSORIMOTOR CORTEX
FUNCTIONAL SUBDIVISIONS OF THE RAT SOMATIC SENSORIMOTOR CORTEX
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DOI：
10.1016/0166-4328(90)90122-u
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发表时间：
1990-06-18
影响因子：
2.7
通讯作者：
SCHALLERT, T
中科院分区：
文献类型：
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作者：
BARTH, TM;JONES, TA;SCHALLERT, T
研究了躯体感觉运动皮质(SMC)局限性单侧损毁大鼠的行为损害和随后的恢复。病变部位包括尾侧前肢区(CFL)、吻侧前肢区(RFL)、前内侧皮质(AMC)或后肢区。在网格表面的探索性运动中，CFL受损的大鼠在放置病变对侧的前肢时产生了缺陷。AMC损伤的大鼠在损伤的同侧方向上绕圈。在双侧刺激试验中，CFL或AMC的病变导致同侧躯体感觉运动不对称(对放置在对侧前肢上的粘贴剂的反应较慢)，在AMC病变后7天或CFL病变后28天内恢复。最后，在双侧刺激任务中，RFL损伤在同侧不对称中产生，更严重和持久(60天内恢复)。在行为恢复后，检查在同侧对侧皮质放置另一个损伤的效果(两期双侧损伤)。在RFL或CFL接受两期双侧损毁的大鼠对第二次损毁对侧前肢的触觉刺激反应较慢。在CFL损伤的大鼠中，放置缺陷也出现在最近一次损伤的对侧。相比之下，接受两阶段双侧AMC损伤的大鼠在第二次损伤后没有表现出行为不对称。这些结果提供了证据，表明损伤/行为学实验可以区分大鼠SMC的亚分红。此外，比较单侧损伤和二期损伤的影响可能有助于将大鼠SMC划分为不同的功能亚区，为研究脑损伤后功能恢复和维持的过程提供基础。
The behavioral impairments and subsequent recovery were studied in rats with circumscribed unilateral lesions in the somatic sensorimotor cortex (SMC). Lesions were made in the caudal forelimb region (CFL), the rostral forelimb region (RFL), the anteromedial cortex (AMC) or the hindlimb area. Rats with damage in the CFL produced a deficit in placing the forelimb contralateral to the lesion during exploratory locomotion on a grid surface. Rats with AMC damage circled in the direction ipsilateral to the lesionl. Lesions in the CFL or AMC produced an ipsilateral somatosensorimotor asymmetry on the bilateral-stimulation test (responding to adhesive patches placed on the contralateral forelimb was slower) that recovered in 7 days following AMC lesions or 28 days following CFL lesions. Finally, RFL lesions produced in ipsilateral asymmetry on the bilateral-stimulation task that was more severe and enduring (recovery in 60 days). After behaviour recovery, the effects of an additional lesion placed in the homotopic contralateral corterx were examined (two-stage bilateral lesion). Rats receiving two-stage bilateral lesions in the RFL or CFL responded slower to tactile stimulation of the forelimb contralateral to the second lesion. In the case of CFL-damaged rats, placing deficits also appeared contralateral to the most recent injury. In contrast, rats receiving two-stage bilateral AMC lesions did not exhibit behavioral asymmetries following the second lesion. These results provide evidence to suggest that subdividsions of the rat SMC can be distinguished with lesion/behavioral experiments. Moreover, a comparion of the effects of unilateral and two-stage lesions may be help in the parcellation of the rat SMC into functionally distinct subareas and provide a basis for studying the processes of recovery and maintenance of function following brain damage.