Functional heterogeneity in dopamine release and in the expression of Fos-like proteins within the rat striatal complex
Functional heterogeneity in dopamine release and in the expression of Fos-like proteins within the rat striatal complex
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DOI：
10.1046/j.1460-9568.1999.00525.x
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发表时间：
1999-04-01
影响因子：
3.4
通讯作者：
Piazza, PV
中科院分区：
文献类型：
--
作者：
Barrot, M;Marinelli, M;Piazza, PV
背外侧纹状体、背外侧核的核和壳是纹状体复合体的三个主要解剖区域。壳被认为是扩展杏仁核的一部分，参与动机和奖励的控制。核心和纹状体被认为是感觉运动整合的中心。在这项研究中，我们比较了这三个区域的反应，轻度压力和药物滥用，通过测量细胞外多巴胺（DA）浓度和Fos样免疫反应（Fos-LI）。结果总结如下。(i)在未受到挑战的条件下，细胞外DA浓度最高的背外侧纹状体和最低的核心，而Fos-LI是最高的壳和最低的背外侧纹状体。(ii)在通过去极化DA能神经元（注射应激或2 mg/kg吗啡）增加DA的挑战后，壳呈现DA水平和Fos LI的最大增加。(iii)DA摄取阻滞剂（15 mg/kg可卡因）给药后，DA的百分比增加仍然是最大的壳。然而，在壳和背外侧纹状体的DA和Fos-LI的绝对增加是相似的。(iv)在完全D-1激动剂（SKF 82958）后，Fos-LI在壳中最高，在背外侧纹状体中最低。总之，核壳似乎是纹状体复合体中对压力和滥用药物最具功能反应的区域。然而，背外侧纹状体和核心似乎功能不同，因为这两个地区的研究的大多数参数不同。
The dorsolateral striatum, and the core and shell of the nucleus accumbens are three major anatomical regions of the striatal complex. The shell is considered as a part of the extended amygdala, and is involved in the control of motivation and reward. The core and the striatum are considered central to sensory motor integration. In this study we compared the responses of these three regions to mild stress and drugs of abuse by measuring extracellular dopamine (DA) concentrations and Fos-like immunoreactivity (Fos-LI). The results are summarrized as follows. (i) In unchallenged conditions, extracellular DA concentrations were highest in the dorsolateral striatum and lowest in the core, whereas Fos-LI was highest in the shell and lowest in the dorsolateral striatum. (ii) After challenges that increase DA by depolarizing DAergic neurons (injection stress or 2 mg/kg morphine), the shell presented the largest increase in DA levels and Fos-LI. (iii) After the administration of a DA-uptake blocker (15 mg/kg cocaine), the percentage increase in DA was still largest in the shell. However, the absolute increase in DA and Fos-LI in the shell and the dorsolateral striatum were similar. (iv) After a full D-1 agonist (SKF82958), Fos-LI was highest in the shell and lowest in the dorsolateral striatum. In conclusion, the nucleus accumbens shell seems to be the area of the striatal complex most functionally reactive to stress and drugs of abuse. However, the dorsolateral striatum and the core appear functionally distinct, as for most of the parameters studied these two regions differed.