ROLE OF HAIR-FOLLICLES IN THE REPIGMENTATION OF VITILIGO
ROLE OF HAIR-FOLLICLES IN THE REPIGMENTATION OF VITILIGO
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DOI：
10.1111/1523-1747.ep12480997
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发表时间：
1991-09-01
影响因子：
6.5
通讯作者：
WANG, GC
中科院分区：
文献类型：
--
作者：
CUI, J;SHEN, LY;WANG, GC
白癜风是一种常见的色素疾病，很难治疗。色素重沉的机制尚不清楚。采用dopa -甲苯胺蓝复合染色、毛囊分裂- dopa染色、毛囊分裂-扫描电镜（SEM）观察了23例正常皮肤、24例白癜风皮肤和36例重色素沉着皮肤的黑色素细胞变化。我们发现在正常皮肤的表皮中只存在活跃的（多巴阳性的）黑素细胞。正常毛囊外根鞘中存在一些失活的（多巴阴性的）黑素细胞，它们构成了人皮肤中的黑素细胞库。白癜风患者表皮的活性黑色素细胞完全缺失，而毛囊外根鞘的非活性黑色素细胞不受影响。治疗刺激毛囊外根鞘中部和/或下部不活跃的黑素细胞分裂、增殖，并沿着外根鞘表面向上迁移到附近的表皮，黑素细胞继续径向迁移，形成临床上见于重色素白癜风病变的色素岛。在向表皮迁移的过程中，黑素细胞从无活性阶段逐渐成熟到活跃状态。总之，这些失活的黑素细胞的存在为白癜风的再色素沉着提供了黑素细胞来源。
Vitiligo is a common pigment disease that is difficult to treat. The mechanism of repigmentation is not known. We combined Dopa-Toluidine Blue complex stain, hair follicle split-Dopa stain, and hair follicle split-scanning electron microscope (SEM) to observe the changes of melanocytes in 23 normal, 24 vitiliginous, and 36 repigmented skin specimens. We found that only active (Dopa-positive) melanocytes existed in the epidermis of normal skin. There were some inactive (Dopa-negative) melanocytes in the outer root sheaths of normal hair follicles, which form the melanocyte reservoir in human skin. In the patients with vitiligo the active melanocytes in the epidermis were totally missing, whereas the inactive melanocytes in the outer root sheaths of hair follicles were not affected. Treatment stimulated the inactive melanocytes in the middle and/or lower parts of the outer root sheaths of hair follicles to divide, proliferate, and migrate upward along the surface of the outer root sheath to the nearby epidermis, where the melanocytes continued to migrate radially to form the pigmented island visible clinically in repigmented vitiligo lesions. During the migration to the epidermis, the melanocytes matured gradually from an inactive phase to an active condition. In conclusion, the existence of these inactive melanocytes provided the melanocyte sources for repigmentation of vitiligo.