Influence of path integration versus environmental orientation on place cell remapping between visually identical environments
Influence of path integration versus environmental orientation on place cell remapping between visually identical environments
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DOI：
10.1152/jn.00132.2005
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发表时间：
2005-10-01
影响因子：
2.5
通讯作者：
Touretzky, DS
中科院分区：
文献类型：
--
作者：
Fuhs, MC;VanRhoads, SR;Touretzky, DS
为了评估角路径整合和视觉地标之间的相互作用对海马神经元放电的影响，我们记录了从CA 1锥体细胞的大鼠觅食在两个相同的盒子与极化的内部线索。在相同方向的条件下，根据斯卡格斯和麦克诺顿早期的实验，盒子的方向相同，并通过走廊连接。在相反方向的条件下，通过将盒子在相反方向上旋转90度来使它们倾斜，因此它们的方向相差180度。经过16 - 23天的预训练相同的方向条件下，三只大鼠经历了这两个条件在平衡的顺序在每一个连续的两天。第三天，他们进行了两次相反方向的试验。虽然斯卡格斯和麦克诺顿观察到稳定的局部“重映射”的地方字段，在这个实验中没有字段重映射在相同的方向条件。在相反方向条件下，第一个盒子中的位置场与相同方向条件下的位置场同构，而在第二个盒子中，大鼠最终表现出完全不同的场。老鼠们对第一次出现这种情况的试验持不同意见。一旦第二个盒子显示出不同的场，它在随后的所有相反方向的试验中继续这样做，然而在随后的相同方向的试验中场保持不变。结果表明，当动物在环境之间积极移动时，因此可能能够保持其惯性角取向，环境取向和大鼠的独特方向感之间的不一致可以深刻地影响海马地图-无论是立即还是作为累积经验的结果。
To assess the effects of interactions between angular path integration and visual landmarks on the firing of hippocampal neurons, we recorded from CA1 pyramidal cells as rats foraged in two identical boxes with polarizing internal cues. In the same- orientation condition, following an earlier experiment by Skaggs and McNaughton, the boxes were oriented identically and connected by a corridor. In the opposite-orientation condition, the boxes were abutted by rotating them 90 degrees in opposite directions, so that their orientations differed by 180 degrees. After 16 - 23 days of pretraining on the same- orientation condition, three rats experienced both conditions in counterbalanced order on each of two consecutive days. On the third day they ran two opposite-orientation trials. Although Skaggs and McNaughton observed stable partial " remapping" of place fields, none of the fields in this experiment remapped in the same- orientation condition. In the opposite-orientation condition, place fields in the first box were isomorphic with those in the same- orientation condition, whereas in the second box the rats eventually exhibited completely different fields. The rats differed as to the trial in which this first occurred. Once the second box exhibited different fields, it continued to do so in all subsequent opposite- orientation trials, yet fields remained the same in subsequent same- orientation trials. The results demonstrate that when animals move actively between environments, and are thus potentially able to maintain their inertial angular orientation, discordance between environmental orientation and the rat's idiothetic direction sense can profoundly affect the hippocampal map - either immediately, or as a result of cumulative experience.