Relationship between epicardial adipose tissue volume and coronary artery spasm
Relationship between epicardial adipose tissue volume and coronary artery spasm
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DOI：
10.1016/j.ijcard.2020.09.074
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发表时间：
2021-01-12
影响因子：
3.5
通讯作者：
Murohara, Toyoaki
中科院分区：
文献类型：
--
作者：
Kataoka, Takashi;Harada, Ken;Murohara, Toyoaki
背景：心外膜脂肪组织（EAT）被认为在血管内皮功能中起关键作用。冠状动脉痉挛被认为是血管内皮异常和动脉粥样硬化的一个致病因素。本研究旨在探讨冠状动脉痉挛与EAT体积、腹部脂肪组织（AAT）总面积和腹部内脏脂肪组织（AVAT）面积之间的关系。方法：在接受冠状动脉计算机断层扫描（CT）评估冠状动脉疾病的患者中，我们确定了110例无明显冠状动脉狭窄的患者，并进行了冠状动脉痉挛激发试验与心导管检查。根据痉挛激发试验结果分为两组：痉挛阳性组和痉挛阴性组。结果：痉挛阳性组77例，痉挛阴性组33例，对照组33例。除了目前吸烟的患病率（48% vs. 27%，p=0.04）外，两组之间的基线临床特征无显著差异。痉挛阳性组的EAT体积显著较高（108 +/- 38 mL vs. 87 +/- 34 mL，p=0.007），而AAT总面积无显著差异（280 ± 113 cm（2）vs. 254 ± 128 cm（2），p=0.32）或AVAT面积（112 ± 54 cm（2）vs. 98 ± 55 cm（2），p=0.27）。多变量logistic分析表明EAT体积（每10 cm（3））（比值比，1.198; 95%可信区间，1.035-1.388; p = 0.016）是冠状动脉痉挛的重要预测因子。结论：我们的结果表明EAT与冠状动脉痉挛有很强的相关性，而AAT可能没有。(C)2020爱思唯尔B. V.保留所有权利。
Background: Epicardial adipose tissue (EAT) is considered to play a critical role in vascular endothelial function. Coronary artery spasm has been postulated to be a causal factor in vascular endothelial abnormalities and atherosclerosis. This study aimed to investigate the relationship between coronary artery spasm and EAT volume, total abdominal adipose tissue (AAT) area, and abdominal visceral adipose tissue (AVAT) area.Method: Among patients undergoing coronary computed tomography (CT) to evaluate coronary artery disease, we identified 110 patients who did not have significant coronary artery stenosis and underwent a coronary spasm provocation test with cardiac catheterization. They were divided into two groups according to the results of the spasm provocation test: spasm-positive and spasm-negative. EAT volume, total AAT area, and AVAT area were evaluated using CT images.Results: Seventy-seven patients were included in the spasm-positive group and 33 patients in the spasm-negative group. There were no significant differences in baseline clinical characteristics between the two groups, except for the prevalence of current smoking (48% vs. 27%, p=0.04). EAT volume was significantly higher in the spasm-positive group (108 +/- 38 mL vs. 87 +/- 34 mL, p=0.007), while no significant difference was seen in total AAT area (280 +/- 113 cm(2) vs. 254 +/- 128 cm(2), p=0.32) or AVAT area (112 +/- 54 cm(2) vs. 98 +/- 55 cm(2), p=0.27). Multivariate logistic analysis indicated that EAT volume (per 10 cm(3)) (odds ratio, 1.198; 95% confidence interval, 1.035-1.388; p = 0.016) was a significant predictor of coronary artery spasm.Conclusion: Our results suggest that EAT has a strong association with coronary artery spasm, while AAT may not. (C) 2020 Elsevier B.V. All rights reserved.