Effect of Lomerizine Hydrochloride on Preventing Strokes in Patients With Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy
Effect of Lomerizine Hydrochloride on Preventing Strokes in Patients With Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy
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盐酸洛美利嗪预防伴有皮质下梗死和白质脑病的常染色体显性遗传性脑动脉病患者脑卒中的效果
DOI：
10.1097/wnf.0000000000000402
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发表时间：
2020
影响因子：
1
通讯作者：
Mizuno Toshiki
中科院分区：
文献类型：
--
作者：
Watanabe-Hosomi Akiko;Mizuta Ikuko;Koizumi Takashi;Yokota Isao;Mukai Mao;Hamano Ai;Kondo Masaki;Fujii Akihiro;Matsui Masaru;Matsuo Koushun;Ito Keita;Teramukai Satoshi;Yamada Kei;Nakagawa Masanori;Mizuno Toshiki
背景常染色体显性遗传性脑动脉病伴皮质下梗死和白质脑病（CADASIL）是一种以偏头痛、复发性中风和痴呆为临床特征的孤儿病。目前，没有疾病修饰疗法，并且难以通过常规抗血栓药物预防CADASIL患者的脑缺血事件。我们假设抗偏头痛药物盐酸洛美利嗪可以预防CADASIL患者的中风，这是基于其增加脑血流量的作用。
BackgroundCerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an orphan disease clinically characterized by migraine, recurrent strokes, and dementia. Currently, there are no disease-modifying therapies, and it is difficult to prevent cerebral ischemic events in CADASIL patients by conventional antithrombotic medication. We hypothesized that an antimigraine agent, lomerizine hydrochloride, may prevent strokes in CADASIL patients, based on its effect on increasing cerebral blood flow.