Sarcopenia is associated with autologous transplant-related outcomes in patients with lymphoma
Sarcopenia is associated with autologous transplant-related outcomes in patients with lymphoma
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DOI：
10.3109/10428194.2015.1014359
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发表时间：
2015-10-03
影响因子：
2.6
通讯作者：
Couriel, Daniel
中科院分区：
文献类型：
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作者：
Caram, Megan V.;Bellile, Emily L.;Couriel, Daniel
肌肉减少症与癌症患者的治疗相关并发症和较短的总生存期相关。对121例接受自体移植的淋巴瘤患者计算腰大肌面积指数。对纳入的73名男性进行年龄、体重指数、合并症和体能状态控制后，非复发死亡率（95%置信区间，CI）为2.37（1.01，5.58），总腰大肌指数每减少100个单位，p = 0.048;瘦腰大肌指数每减少100个单位，p = 0.041。总腰大肌指数较低的男性在移植入院期间经历了更多的并发症（p = 0.001）和住院天数（p = 0.03）。移植后100天内，男性（p < 0.0001）和女性（p <0.0001）的肌肉减少症与住院天数之间存在强相关性。肌肉减少症可能会影响自体移植后的不良结局，从而作为一个潜在的可改变的结局预测因子，并有助于治疗选择。
Sarcopenia is associated with treatment-related complications and shorter overall survival in patients with cancer. Psoas area indices were calculated for 121 patients with lymphoma who underwent autologous transplant. Controlling for age, body mass index, comorbidities and performance status for the 73 men included, the hazard ratio (95% confidence interval, CI) for non-relapse mortality was 2.37 (1.01, 5.58), p = 0.048 for every 100 unit decrease in total psoas index and 2.67 (1.04, 6.86), p = 0.041 for every 100 unit decrease in lean psoas index. Men with a lower total psoas index experienced more complications (p = 0.001) and spent more days in hospital (p = 0.03) during the transplant admission. A strong association existed between sarcopenia and number of hospital days in the 100 days following transplant among both men (p < 0.0001) and women (p < 0.0001). Sarcopenia may impact negative outcomes after autologous transplant thereby serving as a potentially modifiable predictor of outcomes and aiding in treatment selection.