An updated tree of Y-chromosome Haplogroup O and revised phylogenetic positions of mutations P164 and PK4
An updated tree of Y-chromosome Haplogroup O and revised phylogenetic positions of mutations P164 and PK4
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DOI：
10.1038/ejhg.2011.64
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发表时间：
2011-09-01
影响因子：
5.2
通讯作者：
Jin, Li
中科院分区：
文献类型：
--
作者：
Yan, Shi;Wang, Chuan-Chao;Jin, Li
Y染色体单倍群O是东亚人的优势谱系，占世界上所有男性的四分之一以上;然而，其内部的同源性仍然没有得到充分的研究。在这项研究中，我们确定了最近定义的标记（L127，KL1，KL2，P164和PK4）在单倍群O背景下的系统发育位置。在修订后的进化树中，O3a-M324亚群被分为两个主要的分支，O3a1-L127和O3a2-P201，分别覆盖了约20%和35%的中国汉族人。标记P164从M7的下游位置校正到M134的上游，并与M7和M159平行。标记PK4也从M88的下游迁移到M95的上游，将原来的O2 * 分成两部分。这一修订明显提高了东亚Y染色体同源性的分辨能力。欧洲人类遗传学杂志（2011）19，1013 - 1015; doi：10.1038/ejhg.2011.64; 2011年4月20日在线发表
Y-chromosome Haplogroup O is the dominant lineage of East Asians, comprising more than a quarter of all males on the world; however, its internal phylogeny remains insufficiently investigated. In this study, we determined the phylogenetic position of recently defined markers (L127, KL1, KL2, P164, and PK4) in the background of Haplogroup O. In the revised tree, subgroup O3a-M324 is divided into two main subclades, O3a1-L127 and O3a2-P201, covering about 20 and 35% of Han Chinese people, respectively. The marker P164 is corrected from a downstream site of M7 to upstream of M134 and parallel to M7 and M159. The marker PK4 is also relocated from downstream of M88 to upstream of M95, separating the former O2* into two parts. This revision evidently improved the resolving power of Y-chromosome phylogeny in East Asia. European Journal of Human Genetics (2011) 19, 1013-1015; doi: 10.1038/ejhg.2011.64; published online 20 April 2011