A role for histamine and histamine H2-receptors in non-opiate footshock-induced analgesia.
A role for histamine and histamine H2-receptors in non-opiate footshock-induced analgesia.
复制标题
组胺和组胺 H2 受体在非阿片足部电击诱导镇痛中的作用。
DOI：
10.1016/0024-3205(85)90210-3
复制
发表时间：
1985
期刊：
影响因子：
6.1
通讯作者：
Su,K
中科院分区：
文献类型：
--
作者：
Hough,LB;Glick,SD;Su,K
Scrambled DC current applied to the hind paws of rats caused an analgesic response that was inhibited by the histamine H2-receptor antagonists cimetidine, ranitidine and oxmetidine, but not by high doses of naloxone (the opiate antagonist), or other transmitter receptor antagonists. In contrast, AC current applied to all paws produced analgesia that was blocked by naloxone, but not cimetidine, showing the independece of these systems. These findings indicate a specific role for histamine and H2-receptors as mediators of endogenous non-opiate analgesia. In addition, a combination of cimetidine and naloxone did not abolish either form of footshock analgesia, implying the existence of a non-opiate, non-H2, endogenous pain-relieving system. These results also suggest that drugs capable of penetrating the brain and stimulating H2-receptors might have analgesic properties.
