Brain imaging correlates of self- and other-reflection in schizophrenia
Brain imaging correlates of self- and other-reflection in schizophrenia
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DOI：
10.1016/j.nicl.2019.102134
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发表时间：
2020-01-01
影响因子：
4.2
通讯作者：
Salvador, Raymond
中科院分区：
文献类型：
--
作者：
Fuentes-Claramonte, Paola;Martin-Subero, Marta;Salvador, Raymond
背景：自我/他人分化的改变被认为是精神分裂症几种症状的基础，包括参照妄想和社会功能缺陷。与社会认知相关的右颞顶叶交界处（TPJ）功能障碍被认为是这种改变的基础。然而，到目前为止，对精神分裂症患者自我和他人加工的成像研究显示出不一致的结果。方法：对精神分裂症患者和健康对照者在执行自我反思、他人反思和语义加工三种条件下的任务时进行fMRI扫描。结果：与语义处理相比，两组在自我和他人反思方面激活了相似的大脑区域，包括内侧前额叶皮层、楔前叶和TPJ。与健康受试者相比，患者在自我和他人反思时左外侧额叶皮层过度激活。在其他反思中，与自我反思相比，患者未能增加右侧TPJ活性。结论：右侧TPJ活动的改变支持精神分裂症患者自我/他人分化障碍，这可能与精神病症状有关，并影响患者的社会功能。侧额叶皮层在自我和他人反思方面的过度活跃表明，在患者组中，存在更大的认知需求来执行任务。
Background: An alteration in self/other differentiation has been proposed as a basis for several symptoms in schizophrenia, including delusions of reference and social functioning deficits. Dysfunction of the right temporo-parietal junction (TPJ), a region linked with social cognition, has been proposed as the basis of this alteration. However, imaging studies of self- and other-processing in schizophrenia have shown, so far, inconsistent results.Methods: Patients with schizophrenia and healthy controls underwent fMRI scanning while performing a task with three conditions: self-reflection, other-reflection and semantic processing.Results: Both groups activated similar brain regions for self- and other-reflection compared to semantic processing, including the medial prefrontal cortex, the precuneus and the TPJ. Compared to healthy subjects, patients hyperactivated the left lateral frontal cortex during self- and other-reflection. In other-reflection, compared to self-reflection, patients failed to increase right TPJ activity.Conclusions: Altered activity in the right TPJ supports a disturbance in self/other differentiation in schizophrenia, which could be linked with psychotic symptoms and affect social functioning in patients. Hyperactivity of the lateral frontal cortex for self- and other-reflection suggests the presence of greater cognitive demand to perform the task in the patient group.