Polarity-dependent effect of low-frequency stimulation on amygdaloid kindling in rats
Polarity-dependent effect of low-frequency stimulation on amygdaloid kindling in rats
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DOI：
10.1016/j.brs.2012.04.010
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发表时间：
2013-03
影响因子：
7.7
通讯作者：
Zhenghao Xu;Yi Wang;Miaomiao Jin;Jia-xing Yue;Ceng-lin Xu;X. Ying;Dengchang Wu;Shihong Zhang-
中科院分区：
文献类型：
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作者：
Zhenghao Xu;Yi Wang;Miaomiao Jin;Jia-xing Yue;Ceng-lin Xu;X. Ying;Dengchang Wu;Shihong Zhang-
低频刺激（LFS，<5 Hz）已被提议作为治疗癫痫的替代选择。在杏仁核点燃大鼠模型上，LFS的抗癫痫作用与电极极性有关，电极极性对LFS的抗癫痫作用有影响，电极极性对LFS的抗癫痫作用有影响。杏仁核不同极性方向的LFS对杏仁核点燃获得的影响，结果表明，与点燃刺激极性相同而极性相反的双极LFS延迟点燃获得。阳极而不是阴极单极LFS衰减点燃收购和点燃癫痫发作。双极LFS的抗癫痫作用强于单极LFS。此外，阳极LFS（双极和单极）降低，而阴极LFS增加来自杏仁核的EEG的功率;权力的主要变化发生在三角洲地区（0.5-4 Hz）频段，在点燃获得过程中特异性增加。结论我们的结果提供了第一个证据，即点燃灶LFS对大鼠杏仁核点燃的影响是极性依赖性的，这可能是由于正负极LFS对杏仁核活动，特别是对δ带活动的影响不同所致。因此，电极极性，尤其是阳极电流的极性，可能是影响LFS治疗癫痫临床效果的关键因素。
BACKGROUNDLow-frequency stimulation (LFS, <5 Hz) has been proposed as an alternative option for the treatment of epilepsy. The stimulation pole, anode and cathode, may make different contributions to the anti-epileptic effect of LFS.OBJECTIVETo determine whether electrode polarity influences the anti-epileptic effect of LFS at the kindling focus in amygdaloid kindling rats.METHODSThe effect of bipolar and monopolar (or unipolar) LFS at the amygdala in different polarity directions on amygdaloid kindling acquisition, kindled seizures and electroencephalogram (EEG) were tested.RESULTSBipolar LFS in the same direction of polarity as the kindling stimulation but not in the reverse direction retarded kindling acquisition. Anodal rather than cathodal monopolar LFS attenuated kindling acquisition and kindled seizures. Bipolar LFS showed a stronger anti-epileptic effect than monopolar LFS. Furthermore, anodal LFS (both bipolar and monopolar) decreased, while cathodal LFS increased the power of the EEG from the amygdala; the main changes in power were in the delta (0.5–4 Hz) band, which was specifically increased during kindling acquisition.CONCLUSIONSOur results provide the first evidence that the effect of LFS at the kindling focus on amygdaloid kindling in rats is polarity-dependent, and this may be due to the different effects of anodal and cathodal LFS on the activity in the amygdala, especially on the delta band activity. So, It is likely that the electrode polarity, especially that for anodal current, is a key factor affecting the clinical effects of LFS on epilepsy.