Host heme catabolism in drug-sensitive and drug-resistant malaria.
Host heme catabolism in drug-sensitive and drug-resistant malaria.
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药物敏感和耐药疟疾中的宿主血红素分解代谢。
DOI：
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发表时间：
1977
期刊：
影响因子：
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通讯作者：
Engel Rr
中科院分区：
文献类型：
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作者：
Eckman;S. Modler;J. Eaton;E. Berger;Engel Rr
氯喹抗药性在人类和鼠类疟疾中都出现了。小鼠体内的CR伯氏疟原虫不会产生CS型特有的疟疾色素。一氧化碳产生的测定（即，宿主血红素卡他霉素）的研究表明，在所有感染水平下，感染伯氏CS-疟原虫的小鼠产生的一氧化碳仅为感染CR的小鼠的四分之一。这些观察结果证实了疟疾色素是由沉淀的宿主细胞血红蛋白组成的想法，并表明抗药性伴随着寄生虫介导的血红蛋白催化剂的基本改变。
Chloroquine resistance has arisen in both human and murine forms of malaria. CR Plasmodium berghei in mice does not produce the malaria pigment which is characteristic of the CS form. Determinations of carbon monoxide production (i.e., host heme catabolism) by individual mice revealed that those infected with CS P. berghei produce only one fourth as much carbon monoxide as do CR infected mice at all levels of infection. These observations confirm the idea that malaria pigment is composed of precipitated host cell hemoglobin and suggest that drug resistance is accompanied by a basic alteration in parasite-mediated hemoglobin catabolism.