PROXIMAL VERSUS PERIPHERAL HEPATIC-ARTERY EMBOLIZATION - EXPERIMENTAL-STUDY IN MONKEYS
PROXIMAL VERSUS PERIPHERAL HEPATIC-ARTERY EMBOLIZATION - EXPERIMENTAL-STUDY IN MONKEYS
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DOI：
10.1148/128.3.577
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发表时间：
1978-01-01
期刊：
影响因子：
19.7
通讯作者：
KAHN, ER
中科院分区：
文献类型：
--
作者：
DOPPMAN, JL;GIRTON, M;KAHN, ER
一个案件中，广泛栓塞肝动脉，以减少胰岛素生产的转移性胰岛细胞瘤导致肝功能衰竭，肝内脓肿和死亡。通过用明胶海绵和硅胶栓塞恒河猴肝动脉床，研究了近端和外周肝动脉阻塞之间的差异。明胶海绵近端阻塞，动脉侧支迅速发展，肝功能保持正常。用硅胶栓塞外周肝动脉导致肝梗死和严重的功能异常。外周肝动脉阻断在防止侧支循环的发展方面更有效，但涉及肝衰竭或脓肿的显著风险。
A case is described in which extensive embolization of the hepatic artery to reduce insulin production by a metastatic islet-cell tumor resulted in liver failure, intrahepatic abscesses and death. The difference between proximal and peripheral hepatic artery obstruction was investigated in rhesus monkeys by embolizing hepatic arterial beds with Gelfoam and silicone. Gelfoam obstructed proximally, arterial collaterals developed rapidly, and liver function remained normal. Peripheral hepatic artery embolization with silicone produced liver infarction and severe functional abnormalities. Peripheral hepatic artery occlusion was more effective in preventing the development of collateral circulation but involved a significant risk of hepatic failure or abscess.