19 F NMR Spectroscopy as a Highly Sensitive Method for the Direct Monitoring of Confined Crystallization within Nanoporous Materials
19 F NMR Spectroscopy as a Highly Sensitive Method for the Direct Monitoring of Confined Crystallization within Nanoporous Materials
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19 F NMR 波谱作为直接监测纳米多孔材料内限域结晶的高灵敏度方法
DOI：
10.1002/ange.201602936
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发表时间：
2016
影响因子：
--
通讯作者：
Nartowski K
中科院分区：
文献类型：
--
作者：
Nartowski K
在药物结构中引入氟是调整其药效学特性的有效策略，在过去15年中有40多种新药进入市场。在这种情况下，19F核磁共振波谱可以被视为研究纳米药物输送系统中药物的主客体化学的有用方法。尽管人们对限制结晶、纳米器件和多孔催化剂的兴趣正在逐渐增加，但对限制在纳米室或纳米反应器内的有机分子的复杂相行为的理解仍然缺乏。利用19f魔角旋转核磁共振波谱，我们获得了不同孔径（3.2-29 nm）介孔二氧化硅材料在受限环境下氟芬那酸（FFA）结晶的详细机理，为除了晶体受限FFA形式I外，还形成分子-液体样层提供了直接的实验证据。
The introduction of fluorine into the structure of pharmaceuticals has been an effective strategy for tuning their pharmacodynamic properties, with more than 40 new drugs entering the market in the last 15 years. In this context,19F NMR spectroscopy can be viewed as a useful method for investigating the host–guest chemistry of pharmaceuticals in nanosized drug‐delivery systems. Although the interest in confined crystallization, nanosized devices, and porous catalysts is gradually increasing, understanding of the complex phase behavior of organic molecules confined within nanochambers or nanoreactors is still lacking. Using19F magic‐angle‐spinning NMR spectroscopy, we obtained detailed mechanistic insight into the crystallization of flufenamic acid (FFA) in a confined environment of mesoporous silica materials with different pore diameters (3.2–29 nm), providing direct experimental evidence for the formation of a molecular‐liquid‐like layer besides crystalline confined FFA form I.