A higher number of circulating tumor cells (CTC) in peripheral blood indicates poor prognosis in prostate cancer patients--a meta-analysis.
A higher number of circulating tumor cells (CTC) in peripheral blood indicates poor prognosis in prostate cancer patients--a meta-analysis.
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发表时间：
2011
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通讯作者：
Fu Wang;Xue-qin Yang;Shuo Yang;Bicheng Wang;M-H Feng;J. Tu
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作者：
Fu Wang;Xue-qin Yang;Shuo Yang;Bicheng Wang;M-H Feng;J. Tu
目的前列腺癌（PCa）的发病率很高，是世界范围内男性最常见的皮肤癌。尽管进行了大量的研究，但迄今为止，临床实践中很少有PCa的生物标志物被引入。对最近报道的CTC进行了一项荟萃分析，以评估其预后效果，并阐明其在转移性、去势抵抗性前列腺癌（CPRC）和激素难治性前列腺癌（HRPC）患者外周血中的检测是否可以作为生存的预后因素。方法：我们检索了Science Direct、EMBASE、PubMed和Cell Research数据库，以评估外周血（PB）中循环肿瘤细胞（CTC）检测数量与预后的相关性。采用具有相对危险度（RR）和95%置信区间（95% CI）的固定效应模型进行分析。结果4项研究共纳入486例患者，纳入最终分析。合并分析表明，每7.5 ml外周血中CTC的存在数与较差的生存率相关（RR=2.51, 95% CI 1.96-3.21）。结论：不良计数（每7.5 ml外周血中存在5个或更多ctc）与PCa患者的总生存期较差相关。CTC计数可以作为前列腺癌患者生存率的准确和独立的预测指标。
OBJECTIVE The prevalence of prostate cancer (PCa) is high and PCa is the most common cutaneous cancer in men worldwide. Despite extensive research efforts, very few biomarkers of PCa have been introduced to date in clinical practice. A meta-analysis was performed on the most recently reported CTC to assess its prognostic effect and to elucidate whether its detection in the peripheral blood of patients diagnosed with metastatic, castration-resistant prostate cancer (CPRC) and Hormone Refractory Prostate Cancer (HRPC) can be used as a prognostic factor for survival. METHODS We searched Science Direct, EMBASE, PubMed, and Cell Research databases for studies that assessed the prognostic relevance of the presence number of circulating tumor cells (CTC) detection in the peripheral blood (PB). A fixed effects model with relative risk (RR) and 95% confidence interval (95% CI) is used for analysis. RESULTS A total of 4 studies, including 486 patients, were eligible for final analysis. Pooled analysis indicated the presence number of CTC per 7.5 ml peripheral blood is associated with a poor survival rate (RR=2.51, 95% CI 1.96-3.21). CONCLUSION The unfavorable count (presence of 5 or more CTCs per 7.5 ml peripheral blood) was associated with poor overall survival in patients with PCa. CTC counts can be used as an accurate and independent predictor of survival rate in patients with PCa.