Histocompatibility antigen changes associated with pink-eyed dilute (p) mutations.
Histocompatibility antigen changes associated with pink-eyed dilute (p) mutations.
复制标题
与红眼稀释 (p) 突变相关的组织相容性抗原变化。
DOI：
10.1007/bf00364429
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发表时间：
1988
期刊：
影响因子：
3.2
通讯作者：
Birkenmeier,E
中科院分区：
文献类型：
--
作者：
Wettstein,PJ;Chapman,V;Birkenmeier,E
The tight linkage between theH-4histocompatibility locus and the pink-eyed dilute (p) locus raises the possibility that a single gene is responsible for both a histocompatibility antigen and coat color phenotype. To examine this possibility, we have investigated the effects of a spontaneous coat color mutation, pink-eyed unstable (pun), which occurred at theplocus in the C57BL/6J inbred strain, on histocompatibility antigen phenotype. Skin grafts were transplanted from two independently maintained B6punsubstrains to coisogenic, wild-type C57BL/6 recipients; graft rejection uniformly commenced at 6–7 weeks but did not culminate in complete graft destruction as observed in other cases of “crisis” rejection. Neither the onset of rejection time nor the intensity of rejection could be accelerated by introducing newH-2haplotypes into the wild-type recipients. These results suggested that thepunallele was associated with a histocompatibility antigen not shared with C57BL/6. Thepunallele is characterized by a relatively high frequency of reversion to wild-type. Therefore, skin grafts from B6-pundonors were transplanted to homozygous, revertant (+/+) recipients which were subline-matched with the donors; these grafts underwent crisis rejection with the same time of onset of rejection as observed with C57BL/6 recipients. These observations indicate that a new histocompatibility antigen is associated with thepunmutation and is lost upon reversion to wild type; this association is the first demonstration of a link between histocompatibility and coat color phenotypes.
