Decreased Functional Connectivity of Insular Cortex in Drug Naïve First Episode Schizophrenia: In Relation to Symptom Severity.
Decreased Functional Connectivity of Insular Cortex in Drug Naïve First Episode Schizophrenia: In Relation to Symptom Severity.
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初次用药精神分裂症患者岛叶皮质功能连接性下降：与症状严重程度相关
DOI：
10.1371/journal.pone.0167242
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Song X
中科院分区：
文献类型：
--
作者：
Pang L;Kennedy D;Wei Q;Lv L;Gao J;Li H;Quan M;Li X;Yang Y;Fan X;Song X
本研究旨在检查首次发作精神分裂症患者的岛叶皮质功能连接，并探讨连接与临床症状严重程度之间的关系。 37 名未曾用药的精神分裂症患者和 25 名健康对照者参加了这项研究。基于种子的方法用于分析静息态功能成像数据。双侧提取岛叶皮质连接图进行组比较，并通过基于体素的形态测量（VBM）分析进行验证。使用阳性和阴性综合征量表（PANSS）测量临床症状。与健康对照组 (HC) 组相比，患者组的右岛皮质与 Heschl 回、前扣带皮层 (ACC) 和尾状核的连接显着减少 (p<0.001)。 VBM 分析进一步证实了右岛皮质与 Heschl 回的连接减少（FDR 校正 p<0.05）。在患者组中，右侧岛叶-Heschl 连接性与 PANSS 一般精神病理学评分之间存在显着的正相关关系（r = 0.384，p = 0.019）。初次用药的首发精神分裂症患者存在岛叶-Heschl 功能连接减少的情况，这可能与临床症状的表现有关。
This study was to examine the insular cortical functional connectivity in drug naïve patients with first episode schizophrenia and to explore the relationship between the connectivity and the severity of clinical symptoms. Thirty-seven drug naïve patients with schizophrenia and 25 healthy controls were enrolled in this study. A seed-based approach was used to analyze the resting-state functional imaging data. Insular cortical connectivity maps were bilaterally extracted for group comparison and validated by voxel-based morphometry (VBM) analysis. Clinical symptoms were measured using the Positive and Negative Syndrome Scale (PANSS). There were significant reductions in the right insular cortical connectivity with the Heschl’s gyrus, anterior cingulate cortex (ACC), and caudate (p’s<0.001) in the patient group compared with the healthy control (HC) group. Reduced right insular cortical connectivity with the Heschl’s gyrus was further confirmed in the VBM analysis (FDR corrected p<0.05). Within the patient group, there was a significant positive relationship between the right insula-Heschl’s connectivity and PANSS general psychopathology scores (r = 0.384, p = 0.019). Reduced insula-Heschl’s functional connectivity is present in drug naïve patients with first episode schizophrenia, which might be related to the manifestation of clinical symptoms.