Self-Sorting of Two Hydrocarbon Receptors with One Carbonaceous Ligand
Self-Sorting of Two Hydrocarbon Receptors with One Carbonaceous Ligand
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DOI：
10.1002/anie.201609444
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发表时间：
2016-12-05
影响因子：
16.6
通讯作者：
Isobe, Hiroyuki
中科院分区：
文献类型：
--
作者：
Matsuno, Taisuke;Sato, Sota;Isobe, Hiroyuki
非定向货车范德华力在生物和合成超分子体系中起着重要的作用，特别是在确定相互作用物种的距离方面。货车范德华力通常与其他定向力结合使用，并被认为在实现分子识别的特异性和保真度方面起次要作用。使用一个理想的超分子系统，仅由氢和碳原子，我们发现，货车德瓦尔斯相互作用，使高保真分选的两个同源受体在配体诱导的组装。自我排序发生在一个自恋的方式排斥竞争的非对映异构体受体从大会。对映体的结构-分选关系研究进一步揭示了货车德瓦尔斯力在高保真自分选的形状识别中的主导作用。
Non-directional van der Waals forces in biological and synthetic supramolecular systems play important roles in molecular assembly, particularly in determining the distances of the interacting species. The van der Waals forces are normally used in combination with other directional forces and are considered to play a secondary role in achieving specificity and fidelity in molecular recognition. Using an ideal supramolecular system consisting solely of hydrogen and carbon atoms, we found that the van der Waals interactions enable the high-fidelity sorting of two homomeric receptors during ligand-induced assembly. The self-sorting occurred in a narcissistic manner by repulsion of a competing diastereoisomeric receptor from the assembly. The structure-sorting relationship study with enantiomers further revealed the dominant role of the van der Waals forces in shape recognition for high-fidelity self-sorting.