Large non-coding RNAs: missing links in cancer?
Large non-coding RNAs: missing links in cancer?
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DOI：
10.1093/hmg/ddq353
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发表时间：
2010-10-15
影响因子：
3.5
通讯作者：
Rinn, John L.
中科院分区：
文献类型：
--
作者：
Huarte, Maite;Rinn, John L.
细胞内稳态是通过调节网络的适当平衡来实现的，如果被破坏，则可以导致细胞转化。这些细胞回路通过蛋白质和非编码RNA（ncRNA）的协调功能进行微调和维持。除了充分表征的蛋白质编码和microRNA成分之外，大ncRNA也正在成为肿瘤抑制和致癌途径中的重要调控分子。最近的研究揭示了大ncRNA在转录、转录后和表观遗传水平上调节关键癌症通路的机制。在这里，我们综合这些最新进展的背景下，他们的机制作用，调节和维持细胞平衡。与蛋白质编码基因相似，大ncRNA是一类新出现的致癌和抑癌基因。我们对大ncRNA在细胞转化中的作用的了解越来越多，这表明它们在未来可能用作新治疗方法的生物标志物和靶标。
Cellular homeostasis is achieved by the proper balance of regulatory networks that if disrupted can lead to cellular transformation. These cell circuits are fine-tuned and maintained by the coordinated function of proteins and non-coding RNAs (ncRNAs). In addition to the well-characterized protein coding and microRNAs constituents, large ncRNAs are also emerging as important regulatory molecules in tumor-suppressor and oncogenic pathways. Recent studies have revealed mechanistic insight of large ncRNAs regulating key cancer pathways at a transcriptional, post-transcriptional and epigenetic level. Here we synthesize these latest advances within the context of their mechanistic roles in regulating and maintaining cellular equilibrium. We posit that similar to protein-coding genes, large ncRNAs are a newly emerging class of oncogenic and tumor-suppressor genes. Our growing knowledge of the role of large ncRNAs in cellular transformation is pointing towards their potential use as biomarkers and targets for novel therapeutic approaches in the future.