Progesterone receptor antagonist is effective in relieving neuropathic pain
Progesterone receptor antagonist is effective in relieving neuropathic pain
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DOI：
10.1016/j.ejphar.2006.05.010
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发表时间：
2006-07-10
影响因子：
5
通讯作者：
Tanabe, Tsutomu
中科院分区：
文献类型：
--
作者：
Kondo, Daisuke;Yabe, Ritsuko;Tanabe, Tsutomu
小鼠脊神经损伤诱导异常性疼痛和痛觉过敏。鞘内注射孕激素/雌激素受体拮抗剂ICI 182，780产生抗伤害感受作用。雌激素的共同管理没有减少，但往往增强ICI 182，780的抗伤害效应。另一方面，共同给予孕酮剂量依赖性地降低ICI 182，780的抗伤害感受作用，表明抗伤害感受作用是通过ICI 182，780的抗孕酮受体活性。这些结果表明，脊髓孕酮受体在神经病理性疼痛中起重要作用，并且控制孕酮受体的活性可能在神经病理性疼痛的治疗中具有重要意义。(c)2006 Elsevier B.V保留所有权利。
Injury to the spinal nerves of mice induces allodynia and hyperalgesia. Intrathecal injection of the progesterone/estrogen receptor antagonist ICI 182,780 produced antinociceptive effects. Co-administration of estrogen did not reduce but tended to enhance the antinociceptive effect of ICI 182,780. On the other hand, co-administration of progesterone dose-dependently reduced the antimociceptive effect of ICI 182,780, indicating that the antinociceptive effect is through antiprogesterone receptor activity of ICI 182,780. These results suggest that spinal progesterone receptors play an important role in neuropathic pain, and that controlling the activity of progesterone receptors may be of great importance in the treatment of neuropathic pain. (c) 2006 Elsevier B.V All rights reserved.