NONHUMAN PRIMATE MODELS FOR AIDS
NONHUMAN PRIMATE MODELS FOR AIDS
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DOI：
10.1093/clinids/17.supplement_1.s230
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发表时间：
1993-08-01
影响因子：
11.8
通讯作者：
FULTZ, PN
中科院分区：
文献类型：
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作者：
FULTZ, PN
从历史上看，动物模型系统一直是生物医学研究的重要组成部分，对于针对人类免疫缺陷病毒（HIV）大流行的研究也是如此。研究HIV-1和HIV-2感染以及进展为AIDS的最相关和最有价值的模型涉及非人灵长类动物感染HIV-1、HIV-2或一些密切相关的猿免疫缺陷病毒（SIV）。SIV猕猴模型已被证明在艾滋病相关研究的各个方面都很有价值，主要强调定义慢逆转录病毒的致病特性和测试预防和治疗干预的新方法。由于HIV-1黑猩猩模型的某些局限性，尤其是所涉及的费用，HIV-1未感染黑猩猩的使用应仅限于与疫苗开发相关的实验，这是一个已经证明其价值的领域。继续努力阻止艾滋病毒感染的传播和艾滋病毒相关疾病的进展将需要进一步使用这些动物模型。
Historically, animal model systems have been important components of biomedical research, and the same is proving true for research directed at the human immunodeficiency virus (HIV) pandemic. The most relevant and valuable models for studying infection by HIV-1 and HIV-2 and progression to AIDS involve infection of nonhuman primates with HIV-1, HIV-2, or some of the closely related simian immunodeficiency viruses (SIVs). The SIV macaque model has proven valuable in all aspects of AIDS-related research, with primary emphasis on defining pathogenic properties of lentiretroviruses and on testing novel approaches for prophylactic and therapeutic intervention. Because of certain limitations with the HIV-1 chimpanzee model, not the least of which is the expense involved, the use of HIV-naive chimpanzees should be limited to experiments related to vaccine development, an area for which their value has been demonstrated. Continued efforts to halt the spread of HIV infection and progression of HIV-related diseases will require further use of these animal models.