Making waves in Madison: the 6th International Meeting on Zebrafish Development and Genetics.
Making waves in Madison: the 6th International Meeting on Zebrafish Development and Genetics.
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在麦迪逊掀起波澜：第六届斑马鱼发育和遗传学国际会议。
DOI：
10.1089/zeb.2004.1.145
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发表时间：
2004
期刊：
影响因子：
2
通讯作者：
Weinstein,BrantM
中科院分区：
文献类型：
--
作者：
Kamei,Makoto;Kidd,KamehaR;Torres-Vázquez,Jesús;Weinstein,BrantM
第六届国际斑马鱼发育和遗传学会议于2004年7月29日至8月2日在威斯康星州麦迪逊举行，证明了斑马鱼作为模型系统的进展。本次会议上提出的研究范围广泛、质量高，以及演讲引发的热烈讨论，表明斑马鱼已经真正成为一种既定的发育和遗传模型生物。自 1994 年在冷泉港举行第一届斑马鱼发育和遗传学会议以来，会议的规模稳步扩大。该次会议提交了大约 190 份摘要，而今年的摘要超过 640 份。然而，斑马鱼会议及其服务的社区已经以更重要的方式发展。今年会议上展示的个人和合作研究项目的成就水平清楚地表明了这一点。早期的会议包括大量关于基因表达模式、突变表型和克隆项目的报告。这次会议更加强调了基因的复杂功能分析、疾病建模以及利用鱼类中可用的独特研究工具对基本发育问题的深入探索。麦迪逊报道的对这些研究领域的一些贡献如下所述。各种新技术的开发和/或应用极大地促进了斑马鱼研究的深度和复杂性，其中许多新技术在麦迪逊会议上得到了强调。下面还讨论了有关这些技术进步的一些演示。也许麦迪逊报道的最重要的“技术”进步是正在进行的斑马鱼基因组计划工作。 Jane Rogers（桑格中心）描述了测序项目的策略和现状。她宣布最近发布了第四次大会，其中映射了 332,729 个 EST、映射了 4,358 个 cDNA（7,689 个可用的 57%），以及 33,074 个标记中的约 8,300 个进行了独特映射。他们期望在 2005 年完成最终组装。随着测序项目取得进展，获取基因组的能力变得非常重要。为了积极传播基因组信息，Lynn Schriml (NIH)、Judy Sprague (ZFIN) 和 Kerstin Jezosch (Wellcome Trust)
6TH INTERNATIONAL CONFERENCE ON Zebrafish Development and Genetics, held in Madison, Wisconsin from July 29 to August 2, 2004, was a testament to the progress of the zebrafish as a model system. The broad scope and high quality of the research mélange presented at this meeting, and the lively discussion generated by the presentations, showed that the zebrafish has truly arrived as an established developmental and genetic model organism. The meetings have steadily grown in size since the first Zebrafish Development and Genetics Conference held in Cold Spring Harbor in 1994. Approximately 190 abstracts were submitted for that meeting, while this year there were over 640. The zebrafish meeting and the community that it serves have evolved in more important ways, however. This was clearly evident in the level of accomplishment within individual and collaborative research programs on display at this year’s meeting. Earlier meetings included a large amount of reporting on expression patterns of genes, mutant phenotypes, and cloning projects. This meeting saw greater emphasis on the sophisticated functional analysis of genes, disease modeling, and in-depth exploration of basic developmental questions using the unique research tools available in fish. Some of the contributions to these research areas that were reported in Madison are described below. The increased depth and sophistication of zebrafish research has been greatly facilitated by the development and/or application of a wide range of new technologies, many of which were highlighted in Madison. Some of the presentations on these technological advances are also discussed below. Perhaps the most important “technological” advance reported in Madison is the ongoing work on the zebrafish genome project. Jane Rogers (Sanger Center) described the strategy and the status of the sequencing project. She announced the recent release of the 4th assembly with 332,729 ESTs mapped, 4,358 cDNAs mapped (57% of 7,689 available), and approximately 8,300 of 33,074 markers uniquely mapped. They expect to have the final assembly completed in 2005. As progress is made in the sequencing project, the ability to access the genome is important. In a proactive step towards disseminating information on the genome, Lynn Schriml (NIH), Judy Sprague (ZFIN), and Kerstin Jezosch (Wellcome Trust