Polymorphisms of genes coding for ghrelin and its receptor in relation to colorectal cancer risk: a two-step gene-wide case-control study.
Polymorphisms of genes coding for ghrelin and its receptor in relation to colorectal cancer risk: a two-step gene-wide case-control study.
复制标题
DOI：
10.1186/1471-230x-10-112
复制
发表时间：
2010-09-28
影响因子：
2.4
通讯作者：
Canzian F
中科院分区：
文献类型：
--
作者：
Campa D;Pardini B;Naccarati A;Vodickova L;Novotny J;Steinke V;Rahner N;Holinski-Feder E;Morak M;Schackert HK;Görgens H;Kötting J;Betz B;Kloor M;Engel C;Büttner R;Propping P;Försti A;Hemminki K;Barale R;Vodicka P;Canzian F
Ghrelin是生长激素促分泌素受体（GHSR）的内源性配体，具有刺激生长激素产生和刺激食物摄取两大功能。越来越多的证据也表明生长激素释放肽在癌症发展中的作用。我们进行了一项病例对照研究，以检查编码ghrelin（GHRL）及其受体（GHSR）的基因中常见遗传变异与结直肠癌风险的关系。使用成对标记来选择包括在研究中的11个多态性。在捷克共和国的680例病例和593例对照中对选定的多态性进行基因分型。我们发现了两个与结直肠癌风险较低相关的SNPs，即SNPs rs27647和rs35683。我们在来自德国的另外569例病例和726例对照中重复了这两次命中。两个群体的联合分析表明，rs27647 SNP的T等位基因具有保护性边缘效应（Ptrend = 0.004）。
Ghrelin, an endogenous ligand for the growth hormone secretagogue receptor (GHSR), has two major functions: the stimulation of the growth hormone production and the stimulation of food intake. Accumulating evidence also indicates a role of ghrelin in cancer development. We conducted a case-control study to examine the association of common genetic variants in the genes coding for ghrelin (GHRL) and its receptor (GHSR) with colorectal cancer risk. Pairwise tagging was used to select the 11 polymorphisms included in the study. The selected polymorphisms were genotyped in 680 cases and 593 controls from the Czech Republic. We found two SNPs associated with lower risk of colorectal cancer, namely SNPs rs27647 and rs35683. We replicated the two hits, in additional 569 cases and 726 controls from Germany. A joint analysis of the two populations indicated that the T allele of rs27647 SNP exerted a protective borderline effect (Ptrend = 0.004).