Selective intrapartum chemoprophylaxis of neonatal group B streptococcal early-onset disease. II. Predictive value of prenatal cultures.
Selective intrapartum chemoprophylaxis of neonatal group B streptococcal early-onset disease. II. Predictive value of prenatal cultures.
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新生儿 B 族链球菌早发型疾病的选择性产时化学预防。
DOI：
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发表时间：
1983
影响因子：
6.4
通讯作者：
S. Gotoff
中科院分区：
文献类型：
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作者：
K. Boyer;C. Gadzala;P. Kelly;L. Burd;S. Gotoff
为了确定产前培养在确定分娩时母体定植状态中的价值，对5，586名孕妇在产前访视时进行了B组链球菌（GBS）阴道和直肠携带筛查。1,272例（22.8%）分离出GBS。在分娩时，半定量培养获得393产前载体，其中264（67.2%）保留在分娩时携带。17（8.5%）的200名妇女产前培养阴性获得承运。产前培养阳性的预测价值在产前阴道和直肠定植的妇女中最高（72.5%），在仅直肠定植的妇女中最低（59.7%）。预测值与产前采样和分娩之间的时间间隔成反比。在母亲与产前携带，分娩时的殖民密度并没有预测的产前殖民的网站。然而，密度的殖民化，强烈影响新生儿的垂直传播率和婴儿重殖民化率。出生前培养的母亲所生的10名婴儿发生了B组链球菌早发性疾病; 10名中有8名（80%）的母亲产前定植有同源的GBS血清型。
To determine the value of prenatal cultures in defining maternal colonization status at delivery, 5,586 pregnant women were screened at prenatal visits for vaginal and rectal carriage of group B streptococci (GBS). GBS were isolated from 1,272 (22.8%). At delivery, semiquantitative cultures were obtained from 393 prenatal carriers, of whom 264 (67.2%) retained carriage at delivery. Seventeen (8.5%) of 200 women with negative prenatal cultures acquired carriage. The predictive value of a positive prenatal culture was highest (72.5%) in women with prenatal vaginal and rectal colonization and lowest (59.7%) in women with only rectal colonization. The predictive value varied inversely with the interval between prenatal sampling and delivery. In mothers with prenatal carriage, density of colonization at parturition was not predicted by the sites of prenatal colonization. Density of colonization, however, strongly influenced rates of vertical transmission to neonates and rates of heavy infant colonization. Ten infants born to prenatally cultured mothers developed group B streptococcal early-onset disease; the mothers of eight (80%) of the 10 had prenatal colonization with the homologous GBS serotype.