PARENTERAL INFLUENZA VACCINATION INDUCES A RAPID SYSTEMIC AND LOCAL IMMUNE-RESPONSE
PARENTERAL INFLUENZA VACCINATION INDUCES A RAPID SYSTEMIC AND LOCAL IMMUNE-RESPONSE
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DOI：
10.1093/infdis/171.1.198
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发表时间：
1995-01-01
影响因子：
6.4
通讯作者：
LARS, R
中科院分区：
文献类型：
--
作者：
BROKSTAD, KA;COX, RJ;LARS, R
在19名健康受试者中检查了上呼吸道对胃肠外施用的灭活裂解三价流感疫苗的局部免疫应答的动力学。流感病毒特异性抗体分泌细胞（ASC）最早可在接种后2天在外周血和扁桃体中检测到，在接种后1周左右达到峰值，6周后下降至不显著水平。循环中的ASC产生IgG、伊加和IgM，而扁桃体中的ASC主要产生伊加和IgM。血清中流感病毒特异性抗体主要为IgG和IgM，口腔液中伊加; 1周后升高，6周后升高。这可能表明上呼吸道中抗流感病毒反应的分泌参与。肠胃外流感疫苗接种在上呼吸道和外周血中诱导了立即和显著的免疫应答。
The kinetics of the local immune response in the upper respiratory tract to parenterally administered inactivated split trivalent influenza vaccine were examined in 19 healthy subjects. Influenza virus-specific antibody-secreting cells (ASC) could be detected as early as 2 days after vaccination in peripheral blood and tonsils, with a peak at similar to 1 week after vaccination and a decline to insignificant levels after 6 weeks. Circulating ASC produced IgG, IgA, and IgM, whereas ASC in tonsils produced mainly IgA and IgM. Influenza virus-specific antibodies were predominantly IgG and IgM in serum and IgA in oral fluid; they rose after 1 week and were elevated at 6 weeks. This may indicate a secretory involvement of the anti-influenza virus response in the upper respiratory tract. Parenteral influenza vaccination induced an immediate and significant immune response in both the upper respiratory tract and peripheral blood.