Early motor neuron pool identity and muscle nerve trajectory defined by postmitotic restrictions in Nkx6.1 activity
Early motor neuron pool identity and muscle nerve trajectory defined by postmitotic restrictions in Nkx6.1 activity
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DOI：
10.1016/j.neuron.2007.11.033
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发表时间：
2008-01-24
期刊：
影响因子：
16.2
通讯作者：
Jessell, Thomas M.
中科院分区：
文献类型：
--
作者：
Garcia, Natalia V. De Marco;Jessell, Thomas M.
脊髓运动神经元支配其肢体目标肌肉的保真度有助于协调运动行为，但决定神经肌肉连接精确模式的机制仍然不清楚。我们发现，Nkx6蛋白，一组Hox调节的同源结构域转录因子，表达的运动池后不久，运动神经元离开细胞周期，在肢体的肌神经侧支形成之前。使用小鼠遗传学，我们表明，在某些运动神经元池Nkx6.1表达的状态调节肌肉神经的形成，和个别肌肉的神经支配模式。我们的发现提供了遗传学的证据。运动池具有控制靶肌肉特异性的早期转录特性。
The fidelity with which spinal motor neurons innervate their limb target muscles helps to coordinate motor behavior, but the mechanisms that determine precise patterns of nerve-muscle connectivity remain obscure. We show that Nkx6 proteins, a set of Hox-regulated homeodomain transcription factors, are expressed by motor pools soon after motor neurons leave the cell cycle, before the formation of muscle nerve side branches in the limb. Using mouse genetics, we show that the status of Nkx6.1 expression in certain motor neuron pools regulates muscle nerve formation, and the pattern of innervation of individual muscles. Our findings provide genetic evidence that neurons within. motor pools possess an early transcriptional identity that controls target muscle specificity.