A conserved tyrosine in the beta2 subunit M4 segment is a determinant of gamma-aminobutyric acid type A receptor sensitivity to propofol.
A conserved tyrosine in the beta2 subunit M4 segment is a determinant of gamma-aminobutyric acid type A receptor sensitivity to propofol.
复制标题
β2 亚基 M4 片段中的保守酪氨酸是γ-氨基丁酸 A 型受体对丙泊酚敏感性的决定因素。
DOI：
10.1097/01.anes.0000278875.36639.2c
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发表时间：
2007
期刊：
影响因子：
8.8
通讯作者：
Jenkins,Andrew
中科院分区：
文献类型：
--
作者：
Richardson,JamesE;Garcia,PaulS;O'Toole,KateK;Derry,JasonMC;Bell,ShannonV;Jenkins,Andrew
Background: The-aminobutyric acid type A receptor (GABAA-R) subunits are critical targets for the actions for several intravenous general anesthetics, but the precise nature of the anesthetic binding sites are unknown. In addition, little is known about the role the fourth transmembrane (M4) segment of the receptor plays in receptor function. The aim of this study was to better define the propofol binding site on the GABAA-R by conducting a tryptophan scan in the M4 segment of the 2 subunit.Methods: Seven tryptophan mutations were introduced into the
