A culture-brain link: Negative age stereotypes predict Alzheimer's disease biomarkers.
A culture-brain link: Negative age stereotypes predict Alzheimer's disease biomarkers.
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DOI：
10.1037/pag0000062
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发表时间：
2016-02
影响因子：
3.7
通讯作者：
Resnick SM
中科院分区：
文献类型：
--
作者：
Levy BR;Ferrucci L;Zonderman AB;Slade MD;Troncoso J;Resnick SM
虽然消极的年龄刻板印象被发现可以预测老年人的不良后果，但不知道刻板印象的影响是否会延伸到与阿尔茨海默病相关的大脑变化。为了考虑这种可能性，我们借鉴了巴尔的摩老龄化纵向研究中无痴呆症参与者的年龄刻板印象，这些年龄刻板印象是在每年进行核磁共振成像和大脑尸检之前几十年测量的。那些在生命早期有更多负面年龄刻板印象的人，在尸检时有明显更陡峭的脑容量损失，以及明显更多的神经元缠结和淀粉样斑块的积累，调整相关的协变量。这些发现为确定与阿尔茨海默病神经病理学相关的机制和潜在干预措施提供了一条新途径。
Although negative age stereotypes have been found to predict adverse outcomes among older individuals, it was unknown whether the influence of stereotypes extends to brain changes associated with Alzheimer’s disease. To consider this possibility, we drew on the age stereotypes of dementia-free participants in the Baltimore Longitudinal Study of Aging that had been measured decades before yearly MRIs and brain autopsies were performed. Those with more negative age stereotypes earlier in life had significantly steeper hippocampal-volume loss, and significantly greater accumulation of neurofibrillary tangles and amyloid plaques at autopsy, adjusting for relevant covariates. These findings suggest a new pathway to identifying mechanisms and potential interventions related to the neuropathology of Alzheimer’s disease.