Platelet [3H]imipramine binding in affective disorders: trait versus state characteristics.
Platelet [3H]imipramine binding in affective disorders: trait versus state characteristics.
复制标题
情感障碍中的血小板[3H]丙咪嗪结合：特征与状态特征。
DOI：
10.1176/ajp.143.6.711
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Quitkin,F
中科院分区：
文献类型：
--
作者：
Baron,M;Barkai,A;Gruen,R;Peselow,E;Fieve,RR;Quitkin,F
本文测定了67例情感性疾病患者（33例正常双相，34例抑郁单相）和58例正常对照者的血小板[~ 3 H]丙咪嗪结合率（Bmax）。双相患者的Bmax值显著低于对照组。单极患者的平均Bmax低于对照受试者，但差异无统计学意义。解离常数（Kd）值并没有区分患者在任何类别的对照组。在正常的双相情感障碍患者中，Bmax显著降低，在一些但不是所有的单极患者中，Bmax具有明显的状态独立性，这表明血小板丙咪嗪结合可能是情感障碍亚组中的一个特征标志物。
Platelet [3H] imipramine binding (Bmax) was determined in 67 patients with major affective illness (33 euthymic bipolar, 34 depressed unipolar) and 58 normal control subjects. Bipolar patients had significantly lower Bmax values than did control subjects. The mean Bmax in the unipolar patients was lower than in the control subjects, but the difference was not statistically significant. Dissociation constant (Kd) values did not distinguish patients in either category from control subjects. The significantly lower Bmax in euthymic bipolar patients and the apparent state independence of Bmax in some but not all unipolar patients suggest that platelet imipramine binding may be a trait marker in a subset of affective disorders.