Cerebrospinal fluid human immunodeficiency virus type 1 RNA levels are elevated in neurocognitively impaired individuals with acquired immunodeficiency syndrome
Cerebrospinal fluid human immunodeficiency virus type 1 RNA levels are elevated in neurocognitively impaired individuals with acquired immunodeficiency syndrome
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DOI：
10.1002/ana.410420503
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发表时间：
1997-11-01
影响因子：
11.2
通讯作者：
Dupont, R
中科院分区：
文献类型：
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作者：
Ellis, RJ;Hsia, K;Dupont, R
为了确定脑脊液（CSF）病毒负荷测量是否有助于评估人类免疫缺陷病毒（HIV）相关的神经认知障碍，我们定量了CSF中的HIV 1型（HIV-I）RNA。由于先前的研究结果表明，疾病阶段，淋巴细胞增多，血浆中的HIV-1 RNA水平可能会影响CSF病毒负荷，这些变量作为潜在的修改因素进行了检查。通过使用逆转录酶-聚合酶链反应测定来定量HIV-1 RNA水平。在97例前瞻性入组的HIV感染受试者中观察到综合神经心理学（NP）测试的表现。在获得性免疫缺陷综合征（艾滋病）受试者中（
To determine whether cerebrospinal fluid (CSF) viral burden measurements can assist in the evaluation of human immunodeficiency virus (HIV)-associated neurocognitive disorders, we quantified HIV type 1 (HIV-I) RNA in CSF. Because previous findings suggested that disease stage, lymphocytic pleocytosis, and HIV-1 RNA levels in plasma may influence CSF viral burden, these variables were examined as potential modifying factors. HIV-1 RNA levels were quantified by using a reverse transcriptase-polymerase chain reaction assay. Performance on a comprehensive neuropsychological (NP) battery was noted in 97 prospectively enrolled, HIV-infected subjects. Among subjects with acquired immunodeficiency syndrome (AIDS) (