Associations between plasma persistent organic pollutant levels and blood pressure in Inuit adults from Nunavik
Associations between plasma persistent organic pollutant levels and blood pressure in Inuit adults from Nunavik
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DOI：
10.1016/j.envint.2013.06.019
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发表时间：
2013-09-01
影响因子：
11.8
通讯作者：
Dewailly, Eric
中科院分区：
文献类型：
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作者：
Valera, Beatriz;Ayotte, Pierre;Dewailly, Eric
背景：最近的证据表明，接触持久性有机污染物（POP）会增加环境暴露人群患高血压的风险。在北极人群中检测到高 POP 水平，暴露与大量食用鱼类和海洋哺乳动物有关，这些鱼类和海洋哺乳动物代表了这些人群的传统饮食。 目的：我们研究了来自努纳维克（加拿大魁北克省）的因纽特人中多氯联苯 (PCB)、有机氯 (OC) 农药与高血压之间的关系。 方法：获得了 315 名参加“圣魁北克”活动的 18 岁以上因纽特人的完整数据。 1992 年在努纳维克 14 个村庄进行的健康调查。使用电子捕获检测气相色谱法测定了血浆样品中的 14 种多氯联苯 (PCB) 和 8 种 OC 农药或其代谢物。使用标准化方案测量血压（BP），并通过问卷调查获得有关抗高血压药物的信息。使用多元逻辑回归分析对数转换的 POP 与高血压（收缩压 >= 140 mm Hg、舒张压 >= 90 mm Hg 或抗高血压药物）之间的关联。结果：总 PCB 以及非二恶英类 PCB 总和与较高的高血压风险显着相关。此外，高血压的风险随着同源物 101、105、138 和 187 的血浆浓度升高而增加。在纳入 n-3 多不饱和脂肪酸 (PUFA) 后，针对血压风险因素进行调整的模型变得显着，并且对铅和汞的进一步调整并未改变结果。关于有机农药，对，对'-二氯二苯基二氯乙烯 (p,p'-DDE) 与高血压风险增加相关，而对，对'-二氯二苯基三氯乙烷 (p,p'-DDT)、对六氯环己烷 (HCH) 和氯丹则呈负相关。 结论：在这一高暴露人群中，一些 PCB 同源物与高血压风险较高有关。在模型中包含 n-3 PUFA 后，大多数关联变得显着。然而，OC农药的分析显示出不同的结果，需要在进一步的队列和实验研究中得到证实。 (C) 2013 Elsevier Ltd. 保留所有权利。
Background: Recent evidence suggests that exposure to persistent organic pollutants (POPs) increases the risk of hypertension in environmentally exposed populations. High POP levels have been detected in Arctic populations and the exposure is related to high consumption of fish and marine mammals, which represent the traditional diet of these populations.Objective: We examined the associations between polychlorinated biphenyls (PCBs), organochlorine (OC) pesticides and hypertension among Inuit from Nunavik (Quebec, Canada).Methods: A complete set of data was obtained for 315 Inuit >= 18 years who participated in the "Sante Quebec" health survey that was conducted in the 14 villages of Nunavik in 1992. Fourteen polychlorinated biphenyls (PCBs) and 8 OC pesticides or their metabolites were measured in plasma samples using gas chromatography with electron capture detection. Blood pressure (BP) was measured using a standardized protocol and information regarding anti-hypertensive medication was obtained through questionnaires. The associations between log-transformed POPs and hypertension (systolic BP >= 140 mm Hg, diastolic BP >= 90 mm Hg or anti-hypertensive medication) were analyzed using multiple logistic regressions.Results: Total PCBs as well as the sum of non-dioxin-like PCBs were significantly associated with higher risk of hypertension. Furthermore, the risk of hypertension increased with higher plasma concentrations of congeners 101, 105, 138 and 187. Models adjusted for BP risk factors became significant after including n - 3 polyunsaturated fatty acids (PUFAs) and further adjustment for lead and mercury did not change the results. Regarding OC pesticides, p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) was associated with increased risk of hypertension while inverse associations were observed with p,p'-dichlorodiphenyltrichloroethane (p,p'-DDT), p-hexachlorocyclohexane (HCH) and oxychlordane.Conclusions: Some PCB congeners were associated with higher risk of hypertension in this highly exposed population. Most associations became significant after including n - 3 PUFAs in the models. However, the analyses of OC pesticides revealed divergent results, which need to be confirmed in further cohort and experimental studies. (C) 2013 Elsevier Ltd. All rights reserved.