Double casting prototyping with a thermal aging step for fabrication of 3D microstructures in poly(dimethylsiloxane)
Double casting prototyping with a thermal aging step for fabrication of 3D microstructures in poly(dimethylsiloxane)
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DOI：
10.3934/biophy.2016.4.553
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发表时间：
2016-01-01
期刊：
影响因子：
1.5
通讯作者：
Brzozka, Zbigniew
中科院分区：
文献类型：
--
作者：
Kwapiszewska, Karina;Zukowski, Kamil;Brzozka, Zbigniew
本文介绍了一种廉价、易获得的双铸造微加工工艺——热时效处理聚二甲基硅氧烷（PDMS）母材的技术。利用这种技术可以实现三维PDMS微结构。实验证明，热时效可以改变PDMS表面的纳米拓扑结构，从而提高双铸成形的效率。热老化PDMS母材可用于超过98%的制备显微结构的多次和正确复制。此外，缺乏化学修饰保持了PDMS器件的生物相容性。制备的微结构成功地用于三维细胞培养。
The paper describes a cheap and accessible technique of a poly(dimethylsiloxane) (PDMS) master treatment by thermal aging as a step of double casting microfabrication process. Three-dimensional PDMS microstructures could have been achieved using this technique. It was proved, that thermal aging changes nanotopology of a PDMS surface and thus enhances efficiency of double casting prototyping. The thermally aged PDMS master could have been used for multiple and correct replication of over 98% of the fabricated microstructures. Moreover, lack of chemical modification preserved the biocompatibility of PDMS devices. The fabricated microstructures were successfully utilized for 3D cell culture.